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XL647

产品号 S1083 公司名称 Selleck Chemicals
CAS号 651031-01-5 公司网站 http://www.selleckchem.com
分子式 C24H25Cl2FN4O2 电 话 (877) 796-6397
分子量 491.3853032 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 73299

产品价格信息

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产品别名

标题
XL647
IUPAC标准名
7-{[(3aR,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-5-yl]methoxy}-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine
IUPAC传统名
7-{[(3aR,6aS)-2-methyl-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]methoxy}-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine
别名
EXEL-7647

产品登记号

CAS号 651031-01-5

产品性质

作用靶点 EGFR(HER)
成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Biological Activity:
The activity of EXEL-7647 (XL647), a novel spectrum-selective kinase inhibitor with potent activity against the EGF and vascular endothelial growth factor receptor tyrosine kinase families, against both wild-type (WT) and mutant EGFR in vitro and in vivo[1,2] .EXEL-7647 potently inhibits the EGFR and ErbB2 with IC50 0.3 and 16 nM respectively[2] .EXEL-7647 inhibits cellular proliferation and EGFR pathway activation in the erlotinib-resistant H1975 cell line that harbors a double mutation (L858R and T790M) in the EGFR gene. EXEL-7647 substantially inhibited the growth of H1975 xenograft tumors and reduced both tumor EGFR signaling and tumor vessel density. Additionally, EXEL-7647 substantially inhibited the growth and vascularization of MDAMB-231 xenografts, a model which is more reliant on signaling through vascular endothelial growth factor receptors[2] .References on XL647[1] Clin Cancer Res., 2008 Apr 15, 14(8):2465-75.[2] Clin Cancer Res., 2007 Jun 15, 13(12):3713-23

参考文献

  • Trowe T, et al. Clin Cancer Res. 2008 Apr 15;14(8):2465-75.