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651031-01-5 分子结构
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7-{[(3aR,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-5-yl]methoxy}-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine

ChemBase编号:73299
分子式:C24H25Cl2FN4O2
平均质量:491.3853032
单一同位素质量:490.13385964
SMILES和InChIs

SMILES:
n1cnc2c(c1Nc1ccc(c(c1F)Cl)Cl)cc(c(c2)OCC1C[C@@H]2[C@H](C1)CN(C2)C)OC
Canonical SMILES:
COc1cc2c(cc1OCC1C[C@@H]3[C@H](C1)CN(C3)C)ncnc2Nc1ccc(c(c1F)Cl)Cl
InChI:
InChI=1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13?,14-,15+
InChIKey:
HVXKQKFEHMGHSL-GOOCMWNKSA-N

引用这个纪录

CBID:73299 http://www.chembase.cn/molecule-73299.html

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名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
7-{[(3aR,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-5-yl]methoxy}-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine
IUPAC传统名
7-{[(3aR,6aS)-2-methyl-hexahydro-1H-cyclopenta[c]pyrrol-5-yl]methoxy}-N-(3,4-dichloro-2-fluorophenyl)-6-methoxyquinazolin-4-amine
别名
EXEL-7647
XL647
CAS号
651031-01-5
PubChem SID
162038219
PubChem CID
10458325

数据来源

数据来源

所有数据来源 商品来源 非商品来源
数据来源 数据ID 价格
Selleck Chemicals
S1083 external link 加入购物车 请登录
数据来源 数据ID
PubChem 10458325 external link

理论计算性质

理论计算性质

JChem
Acid pKa 13.4573345  质子受体
质子供体 LogD (pH = 5.5) 1.7662418 
LogD (pH = 7.4) 2.8389034  Log P 5.2485213 
摩尔折射率 127.7627 cm3 极化性 50.080173 Å3
极化表面积 59.51 Å2 可自由旋转的化学键
里宾斯基五规则 false 

分子性质

分子性质

安全信息 药理学性质 产品相关信息 生物活性(PubChem)
保存条件
-20°C expand 查看数据来源
作用靶点
EGFR(HER) expand 查看数据来源
成盐信息
Free Base expand 查看数据来源

详细说明

详细说明

Selleck Chemicals Selleck Chemicals
Selleck Chemicals -  S1083 external link
Biological Activity:
The activity of EXEL-7647 (XL647), a novel spectrum-selective kinase inhibitor with potent activity against the EGF and vascular endothelial growth factor receptor tyrosine kinase families, against both wild-type (WT) and mutant EGFR in vitro and in vivo[1,2] .EXEL-7647 potently inhibits the EGFR and ErbB2 with IC50 0.3 and 16 nM respectively[2] .EXEL-7647 inhibits cellular proliferation and EGFR pathway activation in the erlotinib-resistant H1975 cell line that harbors a double mutation (L858R and T790M) in the EGFR gene. EXEL-7647 substantially inhibited the growth of H1975 xenograft tumors and reduced both tumor EGFR signaling and tumor vessel density. Additionally, EXEL-7647 substantially inhibited the growth and vascularization of MDAMB-231 xenografts, a model which is more reliant on signaling through vascular endothelial growth factor receptors[2] .References on XL647[1] Clin Cancer Res., 2008 Apr 15, 14(8):2465-75.[2] Clin Cancer Res., 2007 Jun 15, 13(12):3713-23

参考文献

参考文献

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  • Trowe T, et al. Clin Cancer Res. 2008 Apr 15;14(8):2465-75.
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专利

专利

PubChem iconPubChem Patent Google Patent Search IconGoogle Patent

互联网资源

互联网资源

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