氢化钠

• 产品号: 13431
• CAS号: 7646-69-7
• 分子式: Na+
• 分子量: 22.98977
• 纯 度: 57-63% oil dispersion

产品别名

• 标题: Sodium hydride
• IUPAC标准名: sodium hydride
• IUPAC传统名: sodium hydride

产品登记号

• MDL号: MFCD00003471
• CAS号: 7646-69-7
• 默克索引号: 148625
• EC号: 231-587-3

产品性质

• 纯度: 57-63% oil dispersion
• 外观: Powder
• 密度: 0.92
• 熔点: 800°C dec.
• GHS危险声明: H260
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P231+P232-P280-P233-P370+P378I-P402+P404-P501A
• 危险公开号: 15
• 安全公开号: 7/8-24/25-43
• 保存注意事项: Air & Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 4.3
• 联合国危险货物编号: UN1427
• 联合国危险货物包装类别(PG): I

参考文献

• Used in the deprotonation of DMSO to form "dimsyl sodium", a useful strong base for e.g. the Wittig reaction: J. Org. Chem., 28, 1128 (1963).
• For a review of sodium hydride-based complex reducing agents, see: Acta Chem. Scand., 44, 274 (1990).
• Widely used strong base for the irreversible formation of Na derivatives. If required, the protective oil can be removed by repeated washing and decantation with low-boiling petroleum, see, e.g.: Org. Synth. Coll., 6, 684 (1988), but for many purposes, this is not necessary, and the oil can be removed by incorporating a suitable extraction or washing step in the work-up. There are numerous Organic Syntheses references to reactions using NaH.
• CAUTION! Many literature procedures employ NaH in DMF, and this system is often used routinely by research workers as a 'convenient' general purpose strong base. It should be noted, especially when considering scale-up of such reactions, that thermal runaways have been observed with NaH/ DMF, with self-heating beginning at temperatures as low as 26^oC in some cases: Chem. Eng. News, 60(28), 5; 60(37), 5 (1982). A similar effect was also noted with N,N-dimethylacetamide. More recently also, incidents have been reported with other dipolar aprotic solvents 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (DMPU) and Dimethyl sulfoxide (DMSO): Org. Process. Res. Dev., 7, 1030 (2003).