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Hydralazine hydrochloride

产品号 S2562 公司名称 Selleck Chemicals
CAS号 304-20-1 公司网站 http://www.selleckchem.com
分子式 C8H9ClN4 电 话 (877) 796-6397
分子量 196.63686 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 73106

产品价格信息

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产品别名

标题
Hydralazine hydrochloride
IUPAC标准名
(1Z)-1-hydrazinylidene-1,2-dihydrophthalazine hydrochloride
IUPAC传统名
(1Z)-1-hydrazinylidene-2H-phthalazine hydrochloride
别名
Apresoline

产品登记号

CAS号 304-20-1

产品性质

成盐信息 hydrochloride
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cardiovascular Disease
Biological Activity:
Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. Hydralazine (Apresoline) is used to treat high blood pressure. Hydralazine hydrochloride works by relaxing the blood vessels so that blood can flow more easily through the body. Hydralazine hydrochloride increases guanosine monophosphate levels, decreasing the action of the second messenger IP3, limiting calcium release from the sarcoplasmic reticulum of smooth muscle. This results in vessel relaxation. Hydralazine hydrochloride dilates arterioles more than veins. Hydralazine hydrochloride recently has been identified as a nitric oxide donor. Activation of hypoxia-inducible factors has been suggested as a mechanism. Hydralazine hydrochloride relaxes vascular smooth muscles of arteries and arterioles, causing peripheral vasodilation and decreasing peripheral vascular resistance. These actions decrease blood pressure and increase heart rate, stroke volume, and cardiac output. [1][2][3][4]

参考文献

  • Leitch IM et al. Clin Exp Pharmacol Physiol. 1994 Aug; 21(8):615-22.