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304-20-1 分子结构
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(1Z)-1-hydrazinylidene-1,2-dihydrophthalazine hydrochloride

ChemBase编号:73106
分子式:C8H9ClN4
平均质量:196.63686
单一同位素质量:196.05157399
SMILES和InChIs

SMILES:
c1cc2c(cc1)/c(=N/N)/[nH]nc2.Cl
Canonical SMILES:
N/N=c/1\[nH]ncc2c1cccc2.Cl
InChI:
InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
InChIKey:
ZUXNZUWOTSUBMN-UHFFFAOYSA-N

引用这个纪录

CBID:73106 http://www.chembase.cn/molecule-73106.html

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名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
(1Z)-1-hydrazinylidene-1,2-dihydrophthalazine hydrochloride
IUPAC传统名
(1Z)-1-hydrazinylidene-2H-phthalazine hydrochloride
别名
Apresoline
Hydralazine hydrochloride
CAS号
304-20-1
PubChem SID
162038026
PubChem CID
9351

数据来源

数据来源

所有数据来源 商品来源 非商品来源
数据来源 数据ID 价格
Selleck Chemicals
S2562 external link 加入购物车 请登录
数据来源 数据ID
PubChem 9351 external link

理论计算性质

理论计算性质

JChem
Acid pKa 10.915381  质子受体
质子供体 LogD (pH = 5.5) 0.6238609 
LogD (pH = 7.4) 0.82464707  Log P 0.82807475 
摩尔折射率 59.3336 cm3 极化性 17.269878 Å3
极化表面积 62.77 Å2 可自由旋转的化学键
里宾斯基五规则 true 

分子性质

分子性质

安全信息 产品相关信息 生物活性(PubChem)
保存条件
-20°C expand 查看数据来源
成盐信息
hydrochloride expand 查看数据来源

详细说明

详细说明

Selleck Chemicals Selleck Chemicals
Selleck Chemicals -  S2562 external link
Research Area: Cardiovascular Disease
Biological Activity:
Hydralazine hydrochloride is a hydrochloride salt of hydralazine (Apresoline) that is a direct-acting smooth muscle relaxant with an IC50 of 1.9 mM. Hydralazine (Apresoline) is used to treat high blood pressure. Hydralazine hydrochloride works by relaxing the blood vessels so that blood can flow more easily through the body. Hydralazine hydrochloride increases guanosine monophosphate levels, decreasing the action of the second messenger IP3, limiting calcium release from the sarcoplasmic reticulum of smooth muscle. This results in vessel relaxation. Hydralazine hydrochloride dilates arterioles more than veins. Hydralazine hydrochloride recently has been identified as a nitric oxide donor. Activation of hypoxia-inducible factors has been suggested as a mechanism. Hydralazine hydrochloride relaxes vascular smooth muscles of arteries and arterioles, causing peripheral vasodilation and decreasing peripheral vascular resistance. These actions decrease blood pressure and increase heart rate, stroke volume, and cardiac output. [1][2][3][4]

参考文献

参考文献

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  • Leitch IM et al. Clin Exp Pharmacol Physiol. 1994 Aug; 21(8):615-22.
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专利

专利

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互联网资源

互联网资源

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