2,2,2-三氯乙醇

• 产品号: L08163
• CAS号: 115-20-8
• 分子式: C2H3Cl3O
• 分子量: 149.40362
• 纯 度: 99%

产品别名

• 标题: 2,2,2-Trichloroethanol
• IUPAC标准名: 2,2,2-trichloroethan-1-ol
• IUPAC传统名: trichloroethanol

产品登记号

• EC号: 204-071-0
• Beilstein号: 1697495
• MDL号: MFCD00004677
• CAS号: 115-20-8
• 默克索引号: 149638

产品性质

• 纯度: 99%
• 沸点: 151-153°C
• 密度: 1.560
• 闪点: >110°C(230°F)
• 熔点: 17-18°C
• 折射率: 1.4895
• GHS危险声明: H318-H315-H302-H336
• 欧盟危险性物质标志: X
• GHS警示性声明: P280-P305+P351+P338-P308+P313-P330-P501A
• 危险公开号: 22-38-41-67
• RTECS编号: KM3850000
• 安全公开号: 26-36/37/39
• 保存注意事项: Hygroscopic
• TSCA收录: 是

参考文献

• Carboxyl groups can be protected as their trichloroethyl esters e.g. by tosic acid-catalyzed esterification: Synthesis, 24 (1979), or DCC-DMAP: J. Am. Chem. Soc., 111, 669 (1989). For esterification of amino acids, using the active ester with 2-Hydroxypyridine, A14522, see: Synthesis, 24 (1979). Cleavage occurs with Zn in AcOH or an aqueous THF buffer under mild conditions: J. Am. Chem. Soc., 88, 852 (1966); Synthesis, 457 (1976); or with NaBH₄ in DMF, catalyzed by Se: Synthesis, 693 (1989). See also Appendix 6.
• Similarly, carbonyl compounds can be protected as their trichloroethyl acetals, stable to base, but readily cleaved under neutral aprotic conditions by Zn in ethyl acetate or THF: J. Org. Chem., 38, 554 (1973).
• Reaction with POCl₃ to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuable reagent, usually used without purification, for the phosphorylation of nucleosides: Synthesis, 831 (1980).