(甲基硫代)甲基亚砜甲酯

• 产品号: L00510
• CAS号: 33577-16-1
• 分子式: C3H8OS2
• 分子量: 124.22502
• 纯 度: 97%

产品别名

• 标题: Methyl (methylthio)methyl sulfoxide
• IUPAC标准名: methanesulfinyl(methylsulfanyl)methane
• IUPAC传统名: methanesulfinyl(methylsulfanyl)methane
• 别名: Methyl (methylsulfinyl)methyl sulfide; Formaldehyde dimethyl thioacetal monoxide

产品登记号

• Beilstein号: 906789
• MDL号: MFCD00002091
• CAS号: 33577-16-1
• EC号: 251-577-2

产品性质

• 纯度: 97%
• 沸点: 222-226°C
• 密度: 1.222
• 闪点: >110°C(230°F)
• 折射率: 1.5520
• 保存注意事项: Hygroscopic
• TSCA收录: 是

参考文献

• Readily undergoes metallation with NaH, n-BuLi, etc. to give a useful formaldehyde anion synthon. Products are readily hydrolyzed by acid.
• Monoalkylation with alkyl halides: Tetrahedron Lett., 3151 (1971), or terminal epoxides leads to the homologated aldehydes: J. Org. Chem., 39, 3645 (1974). Dialkylation with alkyl halides affords, after hydrolysis, symmetrical ketones: Synthesis, 117 (1974). This reaction has also been applied to the synthesis of cyclobutanones and other cycloalkanones: Tetrahedron Lett., 3653 (1974); 2767 (1975). A Knoevenagel reaction with aryl aldehydes gives the ketene thioacetal monosulfoxide, readily solvolyzed in alcoholic HCl to an arylacetic ester: Tetrahedron Lett., 1383 (1972):
  
• With ketones, the lithio-derivative gives, after hydrolysis, ɑ-hydroxy aldehydes, not readily available by other routes: Tetrahedron Lett., 2681 (1972). Elimination from the intermediate adduct has also been used as a route to substituted acetic acids: Synthesis, 880 (1979).