N-(三甲基硅基)二乙胺

• 产品号: A18149
• CAS号: 996-50-9
• 分子式: C7H19NSi
• 分子量: 145.31796
• 纯 度: 98%

产品别名

• 标题: N-(Trimethylsilyl)diethylamine
• IUPAC标准名: diethyl(trimethylsilyl)amine
• IUPAC传统名: diethyl(trimethylsilyl)amine
• 别名: TMSDEA; (Diethylamino)trimethylsilane

产品登记号

• EC号: 213-637-6
• MDL号: MFCD00009040
• Beilstein号: 635718
• CAS号: 996-50-9

产品性质

• 纯度: 98%
• 沸点: 125-126°C
• 密度: 0.760
• 闪点: 10°C(50°F)
• 熔点: -10°C
• 折射率: 1.4110
• GHS危险声明: H225-H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 11-34
• 安全公开号: 16-26-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN2733
• 联合国危险货物包装类别(PG): II

参考文献

• Moderately powerful silylating agent which functions as its own base (see Appendix 4). In the silylation of alcohols, the reagent is sensitive to steric effects. Thus, the equatorial hydroxyl group of 3-?-tropanol can be silylated selectively: Acta Chim. Acad. Sci. Hung., 58, 189 (1968); J. Am. Chem. Soc., 96, 5876 (1974).
• In the presence of MeI, primary amines such as aniline are converted to their N,N-bis(trimethylsilyl) derivatives: J. Organomet. Chem., 510, 1 (1996), and ketones to silyl enol ethers in high yield: Organometallics, 16, 2204 (1997). The combination with an alkyl iodide or bromide also provides a convenient method for generating the iodo- or bromotrialkylsilane equivalent in ring-opening of cyclic ethers. With 1 mol of reagent the main product is the ω-siloxy alkyl halide; excess reagent affords the terminal dihalide: J. Org. Chem., 64, 8024 (1999).
• Promotes direct 1,4-addition of ɑ-unsubstituted aldehydes to electron deficient olefins, specifically with enones to give δ-keto aldehydes: J. Chem. Soc., Perkin 1, 316 (2001). Alternative conditions were found to be ineffective.