diethyl(trimethylsilyl)amine

• ChemBase编号: 104757
• 分子式: C7H19NSi
• 平均质量: 145.31796
• 单一同位素质量: 145.12867615
• SMILES: CCN(CC)[Si](C)(C)C
• Canonical SMILES: CCN([Si](C)(C)C)CC
• InChI: InChI=1S/C7H19NSi/c1-6-8(7-2)9(3,4)5/h6-7H2,1-5H3
• InChIKey: JOOMLFKONHCLCJ-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: diethyl(trimethylsilyl)amine
• IUPAC传统名: diethyl(trimethylsilyl)amine
• 别名: N-(三甲基硅基)二乙胺; (二乙氨基)三甲基硅烷; N-(三甲基甲硅烷基)二乙胺; N,N-二乙基三甲基甲硅烷胺; N-(Trimethylsilyl)diethylamine; N-TRIMETHYLSILYL DIETHYLAMINE; TMSDEA; (Diethylamino)trimethylsilane; N-(Trimethylsilyl)diethylamine; N,N-Diethyltrimethylsilylamine; N,N-Diethyl-1,1,1-trimethylsilylamine; N-TRIMETHYLSILYLDIETHYLAMINE

登记号

• CAS号: 996-50-9
• EC号: 213-637-6
• MDL号: MFCD00009040
• Beilstein号: 635718
• PubChem SID: 24859530; 24864626; 24847772; 162091987
• PubChem CID: 70454

理论计算性质

• 质子受体: 1
• 质子供体: 0
• LogD (pH = 5.5): -1.4219337
• LogD (pH = 7.4): -1.3960248
• Log P: 1.8515
• 摩尔折射率: 40.7309 cm^3
• 极化性: 18.099138 Å^3
• 极化表面积: 3.24 Å^2
• 可自由旋转的化学键: 3
• 里宾斯基五规则: true

分子性质

理化性质

• 熔点: -10°C
• 沸点: 125-126 °C(lit.); 125-126°C
• 闪点: 10°C(50°F); 48.2 °F; 9 °C
• 密度: 0.760; 0.767 g/mL at 25 °C(lit.); 0.77 g/ml
• 折射率: 1.4110; n20/D 1.411(lit.); n20/D 1.412
• 蒸汽密度: >1 (vs air)

安全信息

• 保存注意事项: Moisture Sensitive
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C); 易燃性(Flammable) (F)
• 联合国危险货物编号: 2733; UN2733
• 德国WGK号: 3
• 联合国危险货物等级: 3
• 联合国危险货物包装类别(PG): 2; II
• 危险公开号: 11-34; R:34
• 安全公开号: 16-26-36/37/39-45; 26-36/37/39-45; S:26-27/28-36/37/39-46-64
• TSCA收录: 是
• GHS危险品标识: GHS02; GHS05
• GHS警示词: Danger
• GHS危险声明: H225-H314; H225-H314-H318
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A; P210-P280-P305 + P351 + P338-P310
• 个人保护装置: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 2733 3/PG 2

产品相关信息

• 纯度: ≥95.0% (GC); 95%; 97%; 98%
• 级别: derivatization grade; purum; Selectophore™
• 线性分子式: (C2H5)2NSi(CH3)3

详细说明

MP Biomedicals - 05223114

MP Biomedicals Rare Chemical collection

MP Biomedicals - 02157087

(N,N-Diethyl-1,1,1-trimethylsilylamine)
Purity: 95%
1 ml = approx. 0.77 g

Sigma Aldrich - 394890

包装
5 mL in glass bottle

Sigma Aldrich - 127256

包装
25, 100 g in glass bottle

Sigma Aldrich - 32575

Other Notes
硅烷化试剂1,2

Sigma Aldrich - 32574

General description
请访问我们的 传感器应用页面 以了解更多信息。
法律信息
Selectophore 商标 Sigma-Aldrich GmbH

参考文献

• Moderately powerful silylating agent which functions as its own base (see Appendix 4). In the silylation of alcohols, the reagent is sensitive to steric effects. Thus, the equatorial hydroxyl group of 3-?-tropanol can be silylated selectively: Acta Chim. Acad. Sci. Hung., 58, 189 (1968); J. Am. Chem. Soc., 96, 5876 (1974).
• In the presence of MeI, primary amines such as aniline are converted to their N,N-bis(trimethylsilyl) derivatives: J. Organomet. Chem., 510, 1 (1996), and ketones to silyl enol ethers in high yield: Organometallics, 16, 2204 (1997). The combination with an alkyl iodide or bromide also provides a convenient method for generating the iodo- or bromotrialkylsilane equivalent in ring-opening of cyclic ethers. With 1 mol of reagent the main product is the ω-siloxy alkyl halide; excess reagent affords the terminal dihalide: J. Org. Chem., 64, 8024 (1999).
• Promotes direct 1,4-addition of ɑ-unsubstituted aldehydes to electron deficient olefins, specifically with enones to give δ-keto aldehydes: J. Chem. Soc., Perkin 1, 316 (2001). Alternative conditions were found to be ineffective.