N,O-二甲基羟胺盐酸盐

• 产品号: A17469
• CAS号: 6638-79-5
• 分子式: C2H8ClNO
• 分子量: 97.54402
• 纯 度: 98%

产品别名

• 标题: N,O-Dimethylhydroxylamine hydrochloride
• IUPAC标准名: methoxy(methyl)amine hydrochloride
• IUPAC传统名: N,O-dimethylhydroxylamine hydrochloride

产品登记号

• MDL号: MFCD00012485
• Beilstein号: 3650353
• CAS号: 6638-79-5
• EC号: 229-642-1

产品性质

• 纯度: 98%
• 熔点: 112-115°C
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 危险公开号: 36/37/38
• 安全公开号: 26-37
• 保存注意事项: Hygroscopic
• TSCA收录: 是

参考文献

• The N-methoxy-N-methylamides (Weinreb amides) of carboxylic acids, N-protected amino acids and peptides are readily prepared from the acid chloride or mixed anhydride, or from the acid in the presence of 2-Chloro-1-methylpyridinium iodide, A12820: Synth. Commun., 25, 1277 (1995); or BOP Reagent (1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate, A16140): J. Org. Chem., 61, 4999 (1996). The products undergo a number of useful transformations, e.g.:
• Reaction with Grignard or organolithium reagents gives ketones: Tetrahedron Lett., 22, 3815 (1981). Reduction with Lithium aluminum hydride, A18116, gives the aldehyde: Synthesis, 676 (1983). For subsequent conversion of Boc-amino acid derived aldehydes and ketones to pyrrole derivatives, see: J. Org. Chem., 61, 4999 (1996). Coupling with alkyl acetoacetates gives ? δ -diketo esters: Tetrahedron Lett., 29, 6467 (1988). For conversion to ɑ -diketones or ɑ -keto esters, see: J. Org. Chem., 54, 3913 (1989).