三异丙基氯硅烷

• 产品号: A17376
• CAS号: 13154-24-0
• 分子式: C9H21ClSi
• 分子量: 192.80154
• 纯 度: 97+%

产品别名

• 标题: Chlorotriisopropylsilane
• IUPAC标准名: chlorotris(propan-2-yl)silane
• IUPAC传统名: chlorotriisopropylsilane
• 别名: Triisopropylchlorosilane; TIPSCl

产品登记号

• CAS号: 13154-24-0
• MDL号: MFCD00009656
• Beilstein号: 1737446

产品性质

• 纯度: 97+%
• 沸点: 200°C
• 密度: 0.908
• 闪点: 62°C(144°F)
• 折射率: 1.4535
• GHS危险声明: H314-H318-H227
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 34
• 安全公开号: 26-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN2987
• 联合国危险货物包装类别(PG): II

参考文献

• Reagent for the protection of alcohols as triisopropylsilyl (TIPS) ethers. See Appendix 4. Methods of introduction include imidazole in DMF: Tetrahedron Lett., 2865 (1974), or imidazole/DMAP: Chem. Lett., 41 (1987). Also useful for N-protection. The steric bulk of TIPS makes it useful as a regio- and stereodirecting group, allowing selective protection of primary hydroxyl in the presence of secondary: Tetrahedron Lett., 2865 (1974). TIPS ethers are more resistant to acidic hydrolysis than TBDMS ethers, but less so than tert-butyldiphenylsilyl (TBDPS) ethers. However, they are more resistant to basic hydrolysis than either TBDMS or TBDPS derivatives: J. Org. Chem., 45, 4797 (1980); 49, 3239 (1984); Tetrahedron Lett., 24, 3455 (1983).
• Cleavage is usually accomplished by treatment with F^-: J. Org. Chem., 51, 4941 (1986); see Tetra-n-butylammonium fluoride, A10588. Alternative methods include dilute HCl: Tetrahedron Lett., 2865 (1974), or 80% AcOH: J. Carbohydr., Nucleosides, Nucleotides, 3, 197 (1976).
• For a comprehensive review of the TIPS group in organic chemistry, see: Chem. Rev., 95, 1009 (1995). See also Triisopropylsilyl trifluoromethanesulfonate, B21127.