chlorotris(propan-2-yl)silane

• ChemBase编号: 73448
• 分子式: C9H21ClSi
• 平均质量: 192.80154
• 单一同位素质量: 192.11010488
• SMILES: [Si](Cl)(C(C)C)(C(C)C)C(C)C
• Canonical SMILES: CC([Si](C(C)C)(C(C)C)Cl)C
• InChI: InChI=1S/C9H21ClSi/c1-7(2)11(10,8(3)4)9(5)6/h7-9H,1-6H3
• InChIKey: KQIADDMXRMTWHZ-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: chlorotris(propan-2-yl)silane
• IUPAC传统名: chlorotriisopropylsilane
• 别名: 三异丙基氯硅烷; 三异丙氯硅烷; 三异丙基氯甲硅烷; 三异丙氯硅烷; 硅烷 IP3; 三异丙基氯硅烷; Triisopropylsilyl chloride; Chlorotriisopropylsilane; Triisopropylsilyl chloride; Chloro(triisopropyl)silane; Tris(isopropylsilyl) chloride; TIPSCl; Silane IP3; Triisopropylchlorosilane; Triisopropylsilyl chloride; Chlorotriisopropylsilane

登记号

• CAS号: 13154-24-0
• MDL号: MFCD00009656
• Beilstein号: 1737446
• PubChem SID: 24889605; 162038368; 24854324; 24889310; 24873800
• PubChem CID: 139400

理论计算性质

• 质子受体: 0
• 质子供体: 0
• LogD (pH = 5.5): 4.0684
• LogD (pH = 7.4): 4.0684
• Log P: 4.0684
• 摩尔折射率: 50.812 cm^3
• 极化性: 22.042477 Å^3
• 极化表面积: 0.0 Å^2
• 可自由旋转的化学键: 3
• 里宾斯基五规则: true

分子性质

理化性质

• 沸点: 198 °C/739 mmHg(lit.); 200°C; 79-80°C/10mm
• 闪点: 147.2 °F; 62°C; 62°C(144°F); 64 °C
• 密度: 0.901 g/mL at 25 °C(lit.); 0.902; 0.908
• 折射率: 1.4535; n20/D 1.452(lit.)
• 蒸汽压: 1.16 mmHg ( 20 °C)

安全信息

• 保存注意事项: Corrosive/Moisture Sensitive/Store under Argon; Moisture Sensitive
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• 联合国危险货物编号: 2987; UN2987
• 德国WGK号: 3
• 联合国危险货物等级: 8
• 联合国危险货物包装类别(PG): 2; II
• 危险公开号: 34
• 安全公开号: 26-27-36/37/39; 26-36/37/39-45
• TSCA收录: 否
• GHS危险品标识: GHS05
• GHS警示词: Danger
• GHS危险声明: H314; H314-H318-H227
• GHS警示性声明: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A; P280-P305 + P351 + P338-P310
• 个人保护装置: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
• RID/ADR: UN 2987 8/PG 2

产品相关信息

• 纯度: ≥95.0% (GC); ≥97.0% (GC); 90%; 97%; 97+%
• 级别: produced by Wacker; purum; technical grade
• 线性分子式: [(CH3)2CH]3SiCl

详细说明

Sigma Aldrich - 90174

Other Notes
根据要求提供批量采购价

Sigma Aldrich - 241725

Application
TIPS 取代炔烃可用于由铬卡宾络合物制备硅基乙烯基烯酮。1
包装
10, 50 g in glass bottle

Sigma Aldrich - 92090

Other Notes
选择性硅烷化试剂，用于核苷酸合成（TIPS 基团比叔丁基二甲基硅基更耐水解）1,2,3

参考文献

• Reagent for the protection of alcohols as triisopropylsilyl (TIPS) ethers. See Appendix 4. Methods of introduction include imidazole in DMF: Tetrahedron Lett., 2865 (1974), or imidazole/DMAP: Chem. Lett., 41 (1987). Also useful for N-protection. The steric bulk of TIPS makes it useful as a regio- and stereodirecting group, allowing selective protection of primary hydroxyl in the presence of secondary: Tetrahedron Lett., 2865 (1974). TIPS ethers are more resistant to acidic hydrolysis than TBDMS ethers, but less so than tert-butyldiphenylsilyl (TBDPS) ethers. However, they are more resistant to basic hydrolysis than either TBDMS or TBDPS derivatives: J. Org. Chem., 45, 4797 (1980); 49, 3239 (1984); Tetrahedron Lett., 24, 3455 (1983).
• Cleavage is usually accomplished by treatment with F^-: J. Org. Chem., 51, 4941 (1986); see Tetra-n-butylammonium fluoride, A10588. Alternative methods include dilute HCl: Tetrahedron Lett., 2865 (1974), or 80% AcOH: J. Carbohydr., Nucleosides, Nucleotides, 3, 197 (1976).
• For a comprehensive review of the TIPS group in organic chemistry, see: Chem. Rev., 95, 1009 (1995). See also Triisopropylsilyl trifluoromethanesulfonate, B21127.