盐酸羟胺

• 产品号: A15398
• CAS号: 5470-11-1
• 分子式: ClH4NO
• 分子量: 69.49086
• 纯 度: 99%

产品别名

• 标题: Hydroxylamine hydrochloride
• IUPAC标准名: hydroxylamine hydrochloride
• IUPAC传统名: primary amine hydrochloride
• 别名: Hydroxylammonium chloride

产品登记号

• EC号: 226-798-2
• CAS号: 5470-11-1
• MDL号: MFCD00051089
• 默克索引号: 144828
• Beilstein号: 3539763

产品性质

• 纯度: 99%
• 密度: 1.67
• 熔点: 152°C dec.
• GHS危险声明: H200-H351-H373-H290-H315-H319-H400-H302-H312-H317
• 欧盟危险性物质标志: X
• 欧盟危险性物质标志: 爆炸性(Explosive) (E)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P280H-P273-P406
• 危险公开号: 2-21/22-36/38-40-43-48/22-50
• RTECS编号: NC3675000
• 安全公开号: 36/37-61
• 保存注意事项: Hygroscopic
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN2923
• 联合国危险货物包装类别(PG): III

参考文献

• For examples of preparation of oximes from carbonyl compounds, see: Org. Synth. Coll., 2, 70, 313 (1955); 7, 149 (1990). Dehydration of aldoximes is a valuable route to nitriles. The preparation of an oxime, and dehydration with acetic anhydride, are exemplified for veratraldehyde: Org. Synth. Coll., 2, 622 (1943). For other methods of dehydrating oximes to nitriles, see Benzaldoxime, A12053. Procedures for the one-pot conversion of aldehydes to nitriles, without isolation of the intermediate oxime, include: refluxing the aldehyde with hydroxylamine hydrochloride in formic acid/ sodium acetate: J. Chem. Soc., 1564 (1965); formic acid alone: Synthesis, 112 (1979); in pyridine and toluene, with azeotropic water removal: Synthesis, 190 (1982); in DMF (reflux; aromatics only): Z. Chem., 15, 302 (1975); heating in NMP at 110-115^o, effective for aromatic and aliphatic substrates; under these conditions, DMF gave only 20-30% conversion: Synthesis, 586 (1999). A more recent ambient temperature one-pot procedure utilizes DBU in combination with ethyl dichlorophosphate: Synlett, 1317 (2007).
• For a one-pot synthesis of pyrazoles from aldehydes by cyclization of the intermediate oxime in acidic medium with potassium dihyrogen phosphate, see: Tetrahedron Lett., 47, 43 (2006).
• For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1326 (2007).