hydroxylamine hydrochloride

• ChemBase编号: 90809
• 分子式: ClH4NO
• 平均质量: 69.49086
• 单一同位素质量: 68.99814143
• SMILES: NO.Cl
• Canonical SMILES: NO.Cl
• InChI: InChI=1S/ClH.H3NO/c;1-2/h1H;2H,1H2
• InChIKey: WTDHULULXKLSOZ-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: hydroxylamine hydrochloride
• IUPAC传统名: hydroxylamine hydrochloride; primary amine hydrochloride
• 别名: 盐酸羟胺; 羟胺 盐酸盐; 盐酸羟胺, ACS; 盐酸羟胺; Hydroxylammonium chloride; Hydroxylamine hydrochloride 99%; Oxammonium Hydrochloride; HYDROXYLAMINE HYDROCHLORIDE; Hydroxylamine hydrochloride; Hydroxylamine hydrochloride, ACS; HYDROXYLAMINE, ACS

登记号

• CAS号: 5470-11-1
• EC号: 226-798-2
• MDL号: MFCD00051089
• Beilstein号: 3539763
• 默克索引号: 144828
• PubChem SID: 162077539; 24855466; 24879418; 24849814; 24879416; 24863700; 24867012
• PubChem CID: 443297

理论计算性质

• Acid pKa: 17.64608
• 质子受体: 2
• 质子供体: 2
• LogD (pH = 5.5): -0.7521895
• LogD (pH = 7.4): -0.7406456
• Log P: -0.7404964
• 摩尔折射率: 7.8487 cm^3
• 极化性: 2.923362 Å^3
• 极化表面积: 46.25 Å^2
• 可自由旋转的化学键: 0
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: ethanol: clarity passes test; Soluble in water, alcohol, methanol, glycerol
• 外观: Solid
• 熔点: 151°C; 152°C dec.; 155-157 °C (dec.)(lit.); 155-157(dec.)°C
• 密度: 1.67; 1.67 g/ml at 17°C; 1.67 g/mL at 25 °C(lit.); 1.670
• pH值: 2.5-3.5 (25 °C, 50 mg/mL in H2O)

安全信息

• 保存条件: Room Temperature (15-30°C), Desiccate, Store Under Nitrogen
• 保存注意事项: Hygroscopic; Toxic/Corrosive/Explosive/Carcinogenic/Harmful/Air Sensitive/Hygroscopic/Store under Argon
• RTECS编号: NC3675000
• 欧盟危险性物质标志: 爆炸性(Explosive) (E); 环境危害性(Nature polluting) (N); X; 有害性(Harmful) (Xn)
• 联合国危险货物编号: 2923; UN2923
• 德国WGK号: 3
• 联合国危险货物等级: 6.1; 8
• 联合国危险货物包装类别(PG): 2; II; III
• 澳大利亚Hazchem: 2X
• 危险公开号: 2-21/22-36/38-40-43-48/22-50; R:22-36/38-43-48/22-50
• 安全公开号: 36/37-61; S:22-24-37-61
• 欧盟危险货物分类: CT2
• 欧盟危险识别号(EUHIN): 8B
• 美国ERG指导号: 154
• TSCA收录: 是
• GHS危险品标识: GHS01; GHS05; GHS07; GHS08; GHS09
• GHS警示词: Warning
• GHS危险声明: H200-H351-H373-H290-H315-H319-H400-H302-H312-H317; H290-H302-H312-H315-H317-H319-H351-H373-H400
• GHS警示性声明: P273-P280-P305 + P351 + P338; P280H-P273-P406
• 个人保护装置: Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• RID/ADR: UN 2923 8/PG 2

产品相关信息

• 纯度: ≥96.0%; ≥95.0%; ≥96.0%; ≥97.0%; ≥98.0% (RT); ≥99.0%; ≥99.0% (RT); ≥99.9995% (metals basis); 96%; 96+%; 98.0%; 99%; 99.999% trace metals basis; 99.9999% trace metals basis
• 级别: ACS; ACS reagent; for AAS; JIS special grade; puriss. p.a.; purum p.a.; REAGENT; ReagentPlus®; SAJ first grade; TraceSELECT®
• 适用性: suitable for determination of toxic metals
• 燃烧残渣: ≤0.05%; ≤0.05% (as SO4)
• 杂质: <10 ppm total metallic impurities; ≤0.005% S compounds; ≤0.25 meq/g Titr. free acid; ≤0.25 meq/g Titratable free acid
• 痕量阳离子: Ag: ≤0.01 mg/kg; Al: ≤0.05 mg/kg; As: ≤0.005 mg/kg; As: ≤0.01 mg/kg; Ba: ≤0.05 mg/kg; Be: ≤0.01 mg/kg; Bi: ≤0.01 mg/kg; Ca: ≤1 mg/kg; Ca: ≤10 mg/kg; Ca: ≤50 mg/kg; Cd: ≤0.01 mg/kg; Cd: ≤5 mg/kg; Cd: ≤50 mg/kg; Co: ≤0.01 mg/kg; Co: ≤5 mg/kg; Co: ≤50 mg/kg; Cr: ≤0.1 mg/kg; Cr: ≤5 mg/kg; Cs: ≤0.01 mg/kg; Cu: ≤0.2 mg/kg; Cu: ≤5 mg/kg; Cu: ≤50 mg/kg; Fe: ≤0.5 mg/kg; Fe: ≤5 mg/kg; Fe: ≤5 ppm; Fe: ≤50 mg/kg; Ga: ≤0.01 mg/kg; heavy metals (as Pb): ≤5 ppm; heavy metals: ≤5 ppm; Hg: ≤0.001 mg/kg; Hg: ≤0.01 mg/kg; In: ≤0.01 mg/kg; K: ≤0.1 mg/kg; K: ≤100 mg/kg; K: ≤50 mg/kg; Li: ≤0.01 mg/kg; Mg: ≤0.2 mg/kg; Mg: ≤5 mg/kg; Mn: ≤0.05 mg/kg; Mn: ≤5 mg/kg; Mo: ≤0.01 mg/kg; Na: ≤1 mg/kg; Na: ≤100 mg/kg; Na: ≤50 mg/kg; NH4+:, passes test; Ni: ≤0.05 mg/kg; Ni: ≤5 mg/kg; Ni: ≤50 mg/kg; Pb: ≤0.01 mg/kg; Pb: ≤5 mg/kg; Pb: ≤50 mg/kg; Rb: ≤0.01 mg/kg; Sb: ≤0.01 mg/kg; Se: ≤0.01 mg/kg; Sn: ≤0.05 mg/kg; Sr: ≤0.01 mg/kg; Tl: ≤0.01 mg/kg; V: ≤0.01 mg/kg; Zn: ≤0.2 mg/kg; Zn: ≤5 mg/kg; Zn: ≤50 mg/kg
• 痕量阴离子: sulfate (SO42-): ≤50 mg/kg; sulfur compounds (as SO42-): ≤0.005%
• 产品质量级别: PREMIUM
• 线性分子式: NH2OH · HCl

详细说明

MP Biomedicals - 02101997

Hydrochloride
Slowly decomposes when moist.
Purity: 96% minimum

MP Biomedicals - 02152528

Hydrochloride
ACS Reagent Grade
Purity: ≥96.0%

MP Biomedicals - 05213650

MP Biomedicals Rare Chemical collection

Sigma Aldrich - H2391

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。

Sigma Aldrich - 431362

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。
Features and Benefits
符合 A.C.S. 的试剂规范。
包装
50, 250 g in poly bottle
Application
Reactant for preparation of:
• Organosilane amines as potent inhibitors and structural probes of influenza A virus M2 proton channel1
• Lamellarin D analogues as inibitors of topoisomerase I and potential antitumor agents2
• Azapeptide tocolytic agents as inhibitors of prostaglandin F2a receptor for preventing preterm labor3
• Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B4
• Orally bioavailable quinoline-based antidiabetic dipeptidyl peptidase IV inhibitors targeting Lys5545
• Pyrimidine nucleoside derivatives with nitric oxide donors as antiviral agents6
• Benzyladenosine compounds targeting adenosine A2A receptor and adenosine transporter for neuroprotection7
• Naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 with improved potency in rat cystometry models of urinary incontinence8

Sigma Aldrich - 379921

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。
包装
5, 25 g in poly bottle
Application
Reactant for preparation of:
• Organosilane amines as potent inhibitors and structural probes of influenza A virus M2 proton channel1
• Lamellarin D analogues as inibitors of topoisomerase I and potential antitumor agents2
• Azapeptide tocolytic agents as inhibitors of prostaglandin F2α receptor for preventing preterm labor3
• Thiazolidinones spiro-fused to indolin-2-ones as potent and selective inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B4
• Orally bioavailable quinoline-based antidiabetic dipeptidyl peptidase IV inhibitors targeting Lys5545
• Pyrimidine nucleoside derivatives with nitric oxide donors as antiviral agents6
• Benzyladenosine compounds targeting adenosine A2A receptor and adenosine transporter for neuroprotection7
• Naphthol derivatives as inhibitors of the vanilloid receptor TRPV1 with improved potency in rat cystometry models of urinary incontinence8

Sigma Aldrich - 11514

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。
法律信息
TraceSELECT 注册商标 Sigma-Aldrich Co. LLC

Sigma Aldrich - 55459

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。

Sigma Aldrich - 13-2291

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。

Sigma Aldrich - 13-2290

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。

Sigma Aldrich - 255580

Application
强还原剂。可将醛和酮转化为肟，将酰基氯转化为氧肟酸。可用作催化剂、溶胀剂和共聚反应抑制剂。
Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。
包装
100, 500 g in poly bottle
5 g in glass bottle

Sigma Aldrich - 55460

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。

Sigma Aldrich - 13-2280

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。

Sigma Aldrich - 55469

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。

Sigma Aldrich - 159417

Biochem/physiol Actions
MAO 抑制剂;抑制血小板聚集。
包装
100, 500 g in poly bottle
3 kg in poly drum
3kg 开口塑料桶包装；100g、500g 塑料瓶包装
法律信息
ReagentPlus 注册商标 Sigma-Aldrich Co. LLC

参考文献

• For examples of preparation of oximes from carbonyl compounds, see: Org. Synth. Coll., 2, 70, 313 (1955); 7, 149 (1990). Dehydration of aldoximes is a valuable route to nitriles. The preparation of an oxime, and dehydration with acetic anhydride, are exemplified for veratraldehyde: Org. Synth. Coll., 2, 622 (1943). For other methods of dehydrating oximes to nitriles, see Benzaldoxime, A12053. Procedures for the one-pot conversion of aldehydes to nitriles, without isolation of the intermediate oxime, include: refluxing the aldehyde with hydroxylamine hydrochloride in formic acid/ sodium acetate: J. Chem. Soc., 1564 (1965); formic acid alone: Synthesis, 112 (1979); in pyridine and toluene, with azeotropic water removal: Synthesis, 190 (1982); in DMF (reflux; aromatics only): Z. Chem., 15, 302 (1975); heating in NMP at 110-115^o, effective for aromatic and aliphatic substrates; under these conditions, DMF gave only 20-30% conversion: Synthesis, 586 (1999). A more recent ambient temperature one-pot procedure utilizes DBU in combination with ethyl dichlorophosphate: Synlett, 1317 (2007).
• For a one-pot synthesis of pyrazoles from aldehydes by cyclization of the intermediate oxime in acidic medium with potassium dihyrogen phosphate, see: Tetrahedron Lett., 47, 43 (2006).
• For a brief feature on uses of this reagent in Organic synthesis, see: Synlett, 1326 (2007).