溴乙酸叔丁酯

• 产品号: A14917
• CAS号: 5292-43-3
• 分子式: C6H11BrO2
• 分子量: 195.05434
• 纯 度: 98%

产品别名

• 标题: tert-Butyl bromoacetate
• IUPAC标准名: tert-butyl 2-bromoacetate
• IUPAC传统名: tert-butyl 2-bromoacetate
• 别名: Bromoacetic acid tert-butyl ester

产品登记号

• MDL号: MFCD00000188
• Beilstein号: 1753010
• CAS号: 5292-43-3
• EC号: 226-133-6

产品性质

• 纯度: 98%
• 沸点: 175°C
• 密度: 1.330
• 闪点: 49°C(120°F)
• 折射率: 1.4450
• GHS危险声明: H314-H318-H226-H302
• 欧盟危险性物质标志: X
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P280-P303+P361+P353-P305+P351+P338-P310
• 危险公开号: 10-22-34
• 安全公开号: 26-36/37/39-45
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN2924
• 联合国危险货物包装类别(PG): III

参考文献

• In the Reformatsky synthesis of ?-hydroxy acids, competing ?-elimination and retro-aldol type cleavage are minimized by the use of the t-butyl ester, and heating the reaction mixture in dry benzene leads directly to the hydroxy acid, avoiding the need for a separate hydrolysis step: Chem. Commun., 679 (1969); J. Chem. Soc. (C), 2799 (1969). For a review of advances in the Reformatsky reaction, see: Synthesis, 571 (1989). Addition of the same organozinc reagent to nitriles gives amino acrylates, which can be hydrolyzed to ?-keto-esters (Blaise reaction). For extension of this reaction to hindered nitriles, see: J. Org. Chem., 48, 3833 (1983).