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(4S)-(-)-异丙基-2-恶唑啉酮_分子结构_CAS_17016-83-0)
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(4S)-(-)-异丙基-2-恶唑啉酮

产品号 A14029 公司名称 Alfa Aesar
CAS号 17016-83-0 公司网站 http://www.alfa.com
分子式 C6H11NO2 电 话
分子量 129.15704 传 真
纯 度 98% 电子邮件
保 存 Chembase数据库ID: 92245

产品价格信息

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产品别名

标题
(4S)-(-)-Isopropyl-2-oxazolidinone
IUPAC标准名
(4S)-4-(propan-2-yl)-1,3-oxazolidin-2-one
IUPAC传统名
(4S)-4-isopropyl-1,3-oxazolidin-2-one

产品登记号

Beilstein号 3588198
CAS号 17016-83-0
MDL号 MFCD00010847

产品性质

纯度 98%
熔点 70-74°C
比旋光度 -17 (c=6 in ethanol)
TSCA收录

产品详细信息

参考文献

  • Alkyl carboxamides derived from the N-acylation of the oxazolidinone form enolates which undergo highly enantioselective aldol condensation with aldehydes. The products readily undergo hydrolysis, e.g. with base, to give chiral ? -hydroxyacids, with consequent easy recovery and recycle of the chiral auxiliary: J. Am. Chem. Soc., 103, 2127 (1981); Tetrahedron, 27, 897 (1986); Tetrahedron Lett., 31, 4699 (1990); J. Org. Chem., 56, 2489 (1991). For reaction scheme, see (S)-(-)-4-Benzyl-2-oxazolidinone, A18236.
  • The enolates of the N-acyloxazolidinones can also undergo a variety of other enantioselective reactions including alkylation: J. Am. Chem. Soc., 104, 1737 (1982); acylation: J. Am. Chem. Soc., 106, 1154 (1984):
  • Bromination (NBS), followed by azide displacement, gives a route to chiral amino acids: Tetrahedron Lett ., 28, 1123 (1987). Direct electrophilic azidation with triisopropylbenzenesulfonyl azide has also been used to effect this transformation: J. Am. Chem. Soc., 112, 4011 (1990).
  • Chiral auxiliary introduced by Evans for use in enantioselective reactions.
  • See also (S)-(-)-4-Benzyl-2-oxazolidinone, A18236.