1,1,3,3-四甲基胍

• 产品号: A12314
• CAS号: 80-70-6
• 分子式: C5H13N3
• 分子量: 115.17682
• 纯 度: 99%

产品别名

• 标题: 1,1,3,3-Tetramethylguanidine
• IUPAC标准名: 1,1,3,3-tetramethylguanidine
• IUPAC传统名: 1,1,3,3-tetramethylguanidine
• 别名: TMG

产品登记号

• MDL号: MFCD00008323
• CAS号: 80-70-6
• EC号: 201-302-7
• Beilstein号: 969608

产品性质

• 纯度: 99%
• 沸点: 162°C
• 密度: 0.918
• 闪点: 60°C(140°F)
• 熔点: <-30°C
• 折射率: 1.4690
• GHS危险声明: H301-H314-H318-H226
• 欧盟危险性物质标志: X
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 22-34
• 安全公开号: 26-36/37/39-45
• 保存注意事项: Air Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN2920
• 联合国危险货物包装类别(PG): II

参考文献

• Strong organic base useful for the formation of organic-soluble salts, and as a basic catalyst, e.g. in Michael addition reactions: J. Org. Chem., 27, 3175 (1962); Tetrahedron Lett., 569 (1973). Preferred catalyst in the Michael addition of aliphatic nitro compounds to unsaturated esters: Synthesis, 44 (1972); 953 (1989); Tetrahedron Lett., 30, 993 (1989).
• Useful base for formation of TBDMS ethers of alcohols with tert-Butyldimethylchlorosilane, A13064: J. Org. Chem., 49, 4657 (1984).
• Other uses include: Acylation of amino acids by methyl trifluoroacetate: Synthesis, 399 (1976). Formation of Boc-amino acids with tert-butyl phenyl carbonate: Org. Synth. Coll., 6, 203 (1988). Cleavage of peptides from resins: Tetrahedron, 40, 4237 (1984). Selective cleavage of a primary benzyloxycarbonyl (Cbz, Z) group in the presence of either Boc or secondary Cbz: J. Chem. Soc., Perkin 1, 1905 (1988). See also 4-Chloromethylpyridine hydrochloride, A12859 and Appendix 6.
• For use in the Baylis-Hillman reaction, see: J. Chem. Soc., Perkin 1, 2831 (2001).
• Inexpensive and efficient ligand for the palladium-catalyzed Heck reaction: Synlett, 1885 (2005).