Amiloride hydrochloride

• 产品号: Bio-0885
• CAS号: 2016-88-8
• 分子式: C6H9Cl2N7O
• 分子量: 266.08796

产品别名

• 标题: Amiloride hydrochloride
• IUPAC标准名: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
• IUPAC传统名: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
• 别名: Midamor; Amiprazidine; Amipramidin; Amipramizid; Amipramizide; Guanamprazin; Guanamprazine

产品登记号

• CAS号: 2016-88-8

产品性质

• 应用领域: Potassium-sparing diuretic
• 成盐信息: HCl
• 生物活性机理: Inhibitor of sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels.
• 生物活性机理: This promotes the loss of sodium and water from the body, but without depleting potassium.
• 生物活性机理: Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct
• 生物活性机理: this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion.
• 生物活性机理: Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.

参考文献

• Cragoe, E.J. et al., J. Med. Chem., 1967, 10, 66, (synth, pharmacol)
• Smith, R.L. et al., J.A.C.S., 1979, 101, 191, (pmr, cmr, N-15 nmr, tautom)
• Burns, D.T. et al., Anal. Chim. Acta, 1980, 118, 185, (detn, ClO(-))
• Hyams, D.E., Int. Congr. Symp. Ser. R. Soc. Med., 1981, 44, 65, (rev)
• Laragh, J.H., Curr. Ther. Res., 1982, 32, 173, (rev)
• Martindale, The Extra Pharmacopoeia, 28th/29th edn., Pharmaceutical Press, 1982, 2304
• Mazzo, D.J., Anal. Profiles Drug Subst., 1986, 15, 1, (rev)
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 6th edn., Akademie-Verlag, 1987, 445, (synonyms)
• Amiloride and its Analogs, (eds. Cragoe, E.J. et al), VCH, New York, 1992, (book)
• Buono, R.A. et al., J.A.C.S., 1994, 116, 1502, (conformn)