3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride

• ChemBase编号: 72807
• 分子式: C6H9Cl2N7O
• 平均质量: 266.08796
• 单一同位素质量: 265.0245633
• SMILES: c1(c(nc(c(n1)C(=O)NC(=N)N)N)N)Cl.Cl
• Canonical SMILES: NC(=N)NC(=O)c1nc(Cl)c(nc1N)N.Cl
• InChI: InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
• InChIKey: ACHKKGDWZVCSNH-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
• IUPAC传统名: amiloride hydrochloride; amilorida hydrochloride; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride
• 别名: Midamor; Colectril; Amipramizide; Amiloride hydrochloride; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride; Amipramidin; Amipramizid; Amiprazidine; Guanamprazin; Guanamprazine; Amiloride hydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloro-2-pyrazinecarboxamide Hydrochloride; 3,5-Diamino-N-(aminomethyl)-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride; AMILORIDE; N-Amidino-3,5-diamino-6-chlorocyrazinecarboxamide Monohydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinamide Hydrochloride; Amipramidine; Amiprazide; Nilurid

登记号

• CAS号: 2016-88-8
• EC号: 217-958-2
• PubChem SID: 162037728
• PubChem CID: 16230

理论计算性质

• Acid pKa: 11.426196
• 质子受体: 7
• 质子供体: 5
• LogD (pH = 5.5): -0.7251268
• LogD (pH = 7.4): -0.4992728
• Log P: -0.49543247
• 摩尔折射率: 67.1812 cm^3
• 极化性: 19.563002 Å^3
• 极化表面积: 156.79 Å^2
• 可自由旋转的化学键: 1
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: DMSO; Methanol
• 外观: Pale Yellow Solid
• 熔点: 285-288°C; 295-297°C (dec.)

安全信息

• 保存条件: -20°C; Refrigerator, Under Inert Atmosphere; Room Temperature (15-30°C)
• RTECS编号: UQ2275500
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: R:22
• 安全公开号: S:46-36/37/39

药理学性质

• 生物活性机理: Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct;; Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.; Inhibitor of sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels.; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion.; This promotes the loss of sodium and water from the body, but without depleting potassium.

产品相关信息

• 成盐信息: HCl; hydrochloride
• 应用领域: Potassium-sparing diuretic

详细说明

MP Biomedicals - 02153537

Hydrochloride
A sodium ion channel inhibitor.

Selleck Chemicals - S1811

Research Area: Metabolic Disease
Biological Activity:
Amiloride hydrochloride(Midamor), a pyrazine compound inhibit sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. [1]

Toronto Research Chemicals - A578700

Sodium channel blocker. Diuretic.

参考文献

• http://www.drugbank.ca/drugs/DB00594
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