Saxagliptin

• 产品号: S143500
• CAS号: 361442-04-8
• 分子式: C18H25N3O2
• 分子量: 315.41
• 保 存: -20°C Freezer

产品别名

• 标题: Saxagliptin
• IUPAC标准名: (1S,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• IUPAC传统名: (1S,3R,5S)-2-[(2S)-2-amino-2-[(1r,3R,5R,7S)-3-hydroxyadamantan-1-yl]acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile
• 别名: BMS 477118-11; BMS 477118; (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile; Onglyza

产品登记号

• CAS号: 361442-04-8

产品性质

• 外观: White Solid
• 熔点: 107-110°C
• 溶解度: DMSO
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

Saxagliptin is a potent and selective reversible inhibitor of dipeptidyl peptidase-4, which is being developed for the treatment of type 2 diabetes. It is absorbed rapidly after oral administration and has a pharmacokinetic profile compatible with once da

参考文献

• Feng, J., et al.: J. Med. Chem., 50, 2297 (2007)
• Rosenstock, J., et al.: Diabetes Obes. Metab., 10, 376 (2007)
• Thomas, L., et al.: J. Pharmacol. Exp. Ther., 325, 175 (2007)