PF 431396

• 产品号: P218290
• CAS号: 717906-29-1
• 分子式: C22H21F3N6O3S
• 分子量: 506.5007496

产品别名

• 标题: PF 431396
• IUPAC标准名: N-methyl-N-{2-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide
• IUPAC传统名: N-methyl-N-{2-[({2-[(2-oxo-1,3-dihydroindol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]phenyl}methanesulfonamide
• 别名: N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide; N-[2-[[[2-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methylmethanesulfonamide; PF 431396

产品登记号

• CAS号: 717906-29-1

产品详细信息

详细说明 (English)

PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats.

参考文献

• Han, et al.: J. Biol. Chem., 284 13193 (2009)
• Allen, et al.: J. Med. Chem., 53 4332 (2009)