(R)-(+)-Blebbistatin

• 产品号: B592495
• CAS号: 1177356-70-5
• 分子式: C18H16N2O2
• 分子量: 292.33184
• 保 存: -20°C Freezer

产品别名

• 标题: (R)-(+)-Blebbistatin
• IUPAC标准名: (3aR)-3a-hydroxy-6-methyl-1-phenyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
• IUPAC传统名: (3aR)-3a-hydroxy-6-methyl-1-phenyl-2H,3H-pyrrolo[2,3-b]quinolin-4-one
• 别名: (+)-Blebbistatin; (3aR)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one; (+)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one

产品登记号

• CAS号: 1177356-70-5

产品性质

• 外观: Bright Yellow Solid
• 熔点: 210-212°C
• 溶解度: Chloroform
• 溶解度: Dichloromethane
• 溶解度: DMSO
• 溶解度: Ethyl Acetate
• 溶解度: Methanol
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. It blocks both blebbing and cytokinesis at 50-100μM. A negative control for the (S)-(-)-Blebblastatin. [a]D= +110 (c= 1.21 CHCl3) (±)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one Selective inhibitor of nonmuscle myosin II; inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.

参考文献

• Straight, A.F., et al.: Science, 299, 1743 (2003)
• Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2003)
• Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)