Aminopterin

• 产品号: A628850
• CAS号: 54-62-6
• 分子式: C19H20N8O5
• 分子量: 440.4127
• 保 存: -20°C Freezer

产品别名

• 标题: Aminopterin
• IUPAC标准名: (2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid
• IUPAC传统名: 4-aminopteroylglutamic acid
• 别名: 4-Aminofolic Acid, 4-Aminopteroyl-L-glutamic Acid, 4-Amino-PGA; NSC 739; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid

产品登记号

• CAS号: 54-62-6

产品性质

• 外观: Dark Yellow Solid
• 熔点: 208-213°C (dec.)
• 溶解度: DMF
• 溶解度: DMSO
• 保存条件: -20°C Freezer

产品详细信息

详细说明 (English)

A folic acid antagonist. Its actively transported into cells by thefolate transporter. In the cell, its converted to a high molecular weight polyglutamate metabolite by folylpolyglutamate synthase, that, in turn, binds to dihydrofolate reductase and inh

参考文献

• Matherly, L.H., et al.: Cancer Res., 45, 1073 (1985)
• Rumberger, B.G., et al.: Cancer Res., 50, 4639 (1985)
• Roy, K., et al.: J. Biol. Chem., 273, 2526 (1985)