AM 404

• 产品号: A575810
• CAS号: 183718-77-6
• 分子式: C26H37NO2
• 分子量: 395.57748

产品别名

• 标题: AM 404
• IUPAC标准名: (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
• IUPAC传统名: (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
• 别名: (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; (all-Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide

产品登记号

• CAS号: 183718-77-6

产品详细信息

详细说明 (English)

It is a metabolite of the well-known analgesic Paracetamol. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo.

参考文献

• Basile, S., et al.: Pain, 52, 217 (1993)
• Beltramo, M., et al.: Science, 277, 1094 (1993)
• Bisogno, T., et al.: J. Biol. Chem., 272, 3315 (1993)
• Nicholson, R., et al.: Brain Res., 978, 194 (1993)
• La Rana, G., et al.: J. Pharmacol. Exp. Ther., 317, 1365