(5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide

• ChemBase编号: 159753
• 分子式: C26H37NO2
• 平均质量: 395.57748
• 单一同位素质量: 395.28242943
• SMILES: c1c(ccc(c1)NC(=O)CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)O
• Canonical SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)Nc1ccc(cc1)O
• InChI: InChI=1S/C26H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-26(29)27-24-20-22-25(28)23-21-24/h6-7,9-10,12-13,15-16,20-23,28H,2-5,8,11,14,17-19H2,1H3,(H,27,29)/b7-6-,10-9-,13-12-,16-15-
• InChIKey: IJBZOOZRAXHERC-DOFZRALJSA-N

名称和登记号

名称

• IUPAC标准名: (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
• IUPAC传统名: (5Z,8Z,11Z,14Z)-N-(4-hydroxyphenyl)icosa-5,8,11,14-tetraenamide
• 别名: (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; (all-Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; AM 404

登记号

• CAS号: 183718-77-6
• PubChem SID: 162253888
• PubChem CID: 6604822

理论计算性质

• Acid pKa: 9.461591
• 质子受体: 2
• 质子供体: 2
• LogD (pH = 5.5): 7.71786
• LogD (pH = 7.4): 7.714177
• Log P: 7.7179074
• 摩尔折射率: 130.2122 cm^3
• 极化性: 48.05595 Å^3
• 极化表面积: 49.33 Å^2
• 可自由旋转的化学键: 15
• 里宾斯基五规则: false

详细说明

Toronto Research Chemicals - A575810

It is a metabolite of the well-known analgesic Paracetamol. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo.

参考文献

• Basile, S., et al.: Pain, 52, 217 (1993)
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• Bisogno, T., et al.: J. Biol. Chem., 272, 3315 (1993)
• Nicholson, R., et al.: Brain Res., 978, 194 (1993)
• La Rana, G., et al.: J. Pharmacol. Exp. Ther., 317, 1365