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没食子酸丙酯

产品号 48710 公司名称 Sigma Aldrich
CAS号 121-79-9 公司网站 http://www.sigmaaldrich.com
分子式 C10H12O5 电 话 1-800-521-8956
分子量 212.19928 传 真
纯 度 ≥98.0% (HPLC) 电子邮件
保 存 Chembase数据库ID: 102709

产品价格信息

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产品别名

标题
Propyl gallate
IUPAC标准名
propyl 3,4,5-trihydroxybenzoate
IUPAC传统名
propyl gallate
别名
3,4,5-Trihydroxybenzoic acid propyl ester
Tenox PG
3,4,5-三羟基苯甲酸丙酯

产品登记号

EC号 204-498-2
CAS号 121-79-9
PubChem SID 24872242
Beilstein号 1877976
MDL号 MFCD00002196

产品性质

级别 purum
线性分子式 3,4,5-(HO)3C6H2CO2CH2CH2CH3
纯度 ≥98.0% (HPLC)
闪点 187 °C
闪点 368.6 °F
熔点 146-149 °C(lit.)
熔点 146-149 °C
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H302-H317
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS警示性声明 P280
危险公开号 22-43
RTECS编号 LW8400000
安全公开号 24-37
德国WGK号 2

产品详细信息

详细说明 (English)
Reconstitution
Prepare a 0.1M solution in glycerol:PBS (9:1)
Application
Used as an anti-fade reagent in fluorescence microscopy to reduce photobleaching of fluorescent probes such as rhodamine and fluorescein.
Biochem/physiol Actions
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis. However, propyl gallate induced single strand breaks in DNA at concentrations higher than 0.25 μM when it was combined with copper concentrations at 5 μM and above. Another report, however, found that incubation of isolated rat hepatocytes with propyl gallate at concentrations of >1 mM induced cell killing, whereas, a lower concentration of propyl gallate > 0.5 mM resulted in a ladder formation of soluble low-molecular weight DNA fragments, characteristic of apoptosis.
An antioxidant that exhibits antimicrobial activity. Propyl gallate has been reported to be an effective antioxidant-based hepatoprotector, both in vitro and in vivo. It has also been shown to prevent neuronal apoptosis and block the death of neurons exposed to FeSO4/GA as well as partially protect endothelial cells against TNF-induced apoptosis.
详细说明 (简体中文)
Reconstitution
用甘油:PBS (9:1) 配成 0.1M 的溶液
Application
在荧光显微术中用作抗淬灭剂,以减少罗丹明和荧光素等荧光探针的光漂白。
Biochem/physiol Actions
表现出抗菌活性的抗氧化剂。据报道,五倍子酸丙酯是一种有效的、抗氧化剂类体内外护肝剂。另据证明,它能防止神经元凋亡,阻止暴露于 FeSO4/GA 的神经元死亡,以及在一定程度上防止 TNF-诱导的内皮细胞凋亡。
表现出抗菌活性的抗氧化剂。据报道,五倍子酸丙酯是一种有效的、抗氧化剂类体内外护肝剂。另据证明,它能防止神经元凋亡,阻止暴露于 FeSO4/GA 的神经元死亡,以及在一定程度上防止 TNF-诱导的内皮细胞凋亡。但是,当五倍子酸丙酯浓度高于 0.25μM,同时存在 5μM 及更高浓度的铜时,会诱导 DNA 单链断裂。另有报道称,使用浓度 >1mM 的五倍子酸丙酯进行离体大鼠肝细胞培养会诱导细胞死亡,而 >0.5mM 的较低浓度的五倍子酸丙酯导致了可溶性低分子量 DNA 片段的 ladder 形成,这是细胞凋亡的特征。

参考文献