Application Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase. Biochem/physiol Actions Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes. Phenothiazine antipsychotic; D2 dopamine receptor antagonist, H1 histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase. Other Notes Uncouples and inhibits oxidative phoshorylation at 10-3-10-4 M1,2; Interaction of phenothiazine antipsychotics with calmodulin3 |