环孢菌素 A

• 产品号: 80688
• CAS号: 59865-13-3
• 分子式: C62H111N11O12
• 分子量: 1202.61124

产品别名

• 标题: Cyclosporin A
• IUPAC标准名: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• IUPAC传统名: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(1R,2R)-1-hydroxy-2-methylhex-4-en-1-yl]-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• 别名: Cyclosporine; 抗生素 S 7481F1; 环孢霉素; Antibiotic S 7481F1

产品登记号

• Beilstein号: 3647785
• CAS号: 59865-13-3
• MDL号: MFCD00274558

产品性质

• Empirical Formula (Hill Notation): C62H111N11O12
• Pharmacopeia Traceability: traceable to PhEur C2163000
• Pharmacopeia Traceability: traceable to USP 1158504
• GHS警示词: Danger
• GHS危险声明: H302-H350-H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P201-P308 + P313
• 危险公开号: 45-60-22
• RTECS编号: GZ4120000
• 安全公开号: 53-45
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A-cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.

详细说明 (简体中文)

Biochem/physiol Actions
具有强效免疫抑制性的真菌代谢物。它通过形成抑制钙调磷酸酶（蛋白磷酸酶 2B）的环孢菌素 A-亲环蛋白络合物来抑制 T 细胞受体信号转导通路。抑制通过白介素 1α、脂多糖和TNFα 诱导的一氧化氮合成。能够阻断细胞色素 c 从线粒体的释放。