Brefeldin A

• 产品号: 15870
• CAS号: 20350-15-6
• 分子式: C16H24O4
• 分子量: 280.35936
• 纯 度: ≥99.0% (TLC)

产品别名

• 标题: Brefeldin A
• IUPAC标准名: (1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
• IUPAC传统名: brefeldin A
• 别名: γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone; Ascotoxin; Cyanein; Decumbin; BFA

产品登记号

• MDL号: MFCD12913297
• Beilstein号: 25191
• CAS号: 20350-15-6

产品性质

• 生物来源: from Penicillium brefeldianum
• Empirical Formula (Hill Notation): C16H24O4
• 纯度: ≥99.0% (TLC)
• 熔点: 200-205 °C
• 溶解度: methanol: soluble10 mg/mL, clear, colorless to faintly yellow
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22
• RTECS编号: GY8410000
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Other Notes
Effects a rapid increase of Golgi cisternae volume and subsequent loss of recognizable Golgi apparatus in treated cells1,2.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.

详细说明 (简体中文)

Other Notes
Effects a rapid increase of Golgi cisternae volume and subsequent loss of recognizable Golgi apparatus in treated cells1,2.
Biochem/physiol Actions
Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.