Osteoprotegerin/Fc Chimera from mouse

• 产品号: O8137
• 分子式: C18H32O2
• 分子量: 280.44548
• 纯 度: >95% (SDS-PAGE)

产品别名

• 标题: Osteoprotegerin/Fc Chimera from mouse
• IUPAC标准名: octadec-7-ynoic acid
• IUPAC传统名: 7-octadecynoic acid
• 别名: OPG; OCIF

产品登记号

• MDL号: MFCD01867131
• PubChem SID: 24898055

产品性质

• 杂质: endotoxin, tested
• Mol. Weight: calculated mol wt 70.9 kDa
• Mol. Weight: mol wt 100 kDa by SDS-PAGE (reducing)
• 纯度: >95% (SDS-PAGE)
• 基因表达载体: expressed in NSO cells
• 相关基因信息: mouse ... Tnfrsf11b(18383)
• 外观: lyophilized powder
• 保存温度: -20°C

产品详细信息

详细说明 (English)

Analysis Note
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
General description
Mouse OPG (amino acids 22-401) is fused downstream of the human IL-3Rα signal sequence to the C-terminal histidine-tagged Fc portion of human IgG1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Biochem/physiol Actions
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.

详细说明 (简体中文)

Analysis Note
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
General description
Mouse OPG (amino acids 22-401) is fused downstream of the human IL-3Rα signal sequence to the C-terminal histidine-tagged Fc portion of human IgG1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Biochem/physiol Actions
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.