octadec-7-ynoic acid

• ChemBase编号: 155658
• 分子式: C18H32O2
• 平均质量: 280.44548
• 单一同位素质量: 280.24023026
• SMILES: CCCCCCCCCCC#CCCCCCC(=O)O
• Canonical SMILES: CCCCCCCCCCC#CCCCCCC(=O)O
• InChI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-10,13-17H2,1H3,(H,19,20)
• InChIKey: XXUPLYBCNPLTIW-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: octadec-7-ynoic acid
• IUPAC传统名: 7-octadecynoic acid
• 别名: OCIF; OPG; Osteoprotegerin/Fc Chimera from mouse

登记号

• MDL号: MFCD01867131
• PubChem SID: 24898055; 162249796
• PubChem CID: 4378574

理论计算性质

• Acid pKa: 4.5601563
• 质子受体: 2
• 质子供体: 1
• LogD (pH = 5.5): 5.74448
• LogD (pH = 7.4): 3.9707086
• Log P: 6.730427
• 摩尔折射率: 85.647 cm^3
• 极化性: 33.30096 Å^3
• 极化表面积: 37.3 Å^2
• 可自由旋转的化学键: 15
• 里宾斯基五规则: false

分子性质

理化性质

• 外观: lyophilized powder

安全信息

• 保存温度: -20°C

药理学性质

• 相关基因信息: mouse ... Tnfrsf11b(18383)

产品相关信息

• 纯度: >95% (SDS-PAGE)
• 杂质: endotoxin, tested
• 基因表达载体: expressed in NSO cells
• Mol. Weight: calculated mol wt 70.9 kDa; mol wt 100 kDa by SDS-PAGE (reducing)

详细说明

Sigma Aldrich - O8137

Analysis Note
The biological activity is measured by its ability to neutralize apoptosis of mouse L-929 cells treated with 50 ng/ml recombinant human TRAIL.
General description
Mouse OPG (amino acids 22-401) is fused downstream of the human IL-3Rα signal sequence to the C-terminal histidine-tagged Fc portion of human IgG1.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Biochem/physiol Actions
OPG is a soluble secreted member of the tumor necrosis factor receptor superfamily that lacks any apparent cell-association motifs. It regulates the formation of osteoclasts and is involved in the regulation of bone resorption and remodeling. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG.