IWR-1

• 产品号: I0161
• 分子式: C25H19N3O3
• 分子量: 409.43666
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: IWR-1
• IUPAC标准名: 4-[(1R,2S,6R,7S)-3,5-dioxo-4-azatricyclo[5.2.1.0^2,^6]dec-8-en-4-yl]-N-(quinolin-8-yl)benzamide
• IUPAC传统名: iwr-1-endo
• 别名: IWR1; 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinyl-Benzamide

产品性质

• Empirical Formula (Hill Notation): C25H19N3O3
• 纯度: ≥98% (HPLC)
• 外观: tan
• 溶解度: DMSO: ≥10 mg/mL
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
The Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).

详细说明 (简体中文)

Biochem/physiol Actions
The Wnt/b-catenin (‘canonical’) pathway maintains transcriptional programs that enable stem cells to remain multipotent. Hyperactivation of the Wnt/b-catenin pathway leads to disease stage. IWR-3 act as inhibitors of Wnt response. It appear that IWR compounds induce stabilization of Axin proteins via a direct interaction, which is a part of the b-catenin destruction complex (consists of Apc, Axin, Ck1 and Gsk3b).