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乌头碱

产品号 A8001 公司名称 Sigma Aldrich
CAS号 302-27-2 公司网站 http://www.sigmaaldrich.com
分子式 C34H47NO11 电 话 1-800-521-8956
分子量 645.73708 传 真
纯 度 ≥95% (HPLC) 电子邮件
保 存 Chembase数据库ID: 138938

产品价格信息

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产品别名

标题
Aconitine
IUPAC标准名
(2R,3R,4R,5R,6S,7S,8R,9R,10S,13R,14R,16R,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl benzoate
IUPAC传统名
(2R,3R,4R,5R,6S,7S,8R,9R,10S,13R,14R,16R,18R)-8-(acetyloxy)-11-ethyl-5,7,14-trihydroxy-6,16,18-trimethoxy-13-(methoxymethyl)-11-azahexacyclo[7.7.2.12,5.01,10.03,8.013,17]nonadecan-4-yl benzoate
别名
Acetylbenzoylaconine
乙酰苯甲酰阿康碱

产品登记号

EC号 206-121-7
PubChem SID 24891304
MDL号 MFCD00082375
Beilstein号 74608
CAS号 302-27-2

产品性质

Empirical Formula (Hill Notation) C34H47NO11
纯度 ≥95% (HPLC)
外观 white crystalline
溶解度 H2O: soluble0.3 mg/mL
溶解度 ethanol: soluble35 mg/mL
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H300-H330
欧盟危险性物质标志 剧毒(Highly toxic) 剧毒(Highly toxic) (T+)
MSDS下载 下载链接
个人保护装置 Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
GHS警示性声明 P260-P264-P284-P310
RID/ADR UN 1544 6.1/PG 1
危险公开号 26/28
RTECS编号 AR5960000
安全公开号 24-45
联合国危险货物等级 6.1
联合国危险货物编号 1544
联合国危险货物包装类别(PG) 1
德国WGK号 2

产品详细信息

详细说明 (English)
Application
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Biochem/physiol Actions
Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.
详细说明 (简体中文)
Application
Aconitine is a neurotoxin which activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization and blocking the release of neurotransmitters. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection.
Biochem/physiol Actions
Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization.

参考文献