N-琥珀酰亚胺基-S-乙酰硫基乙酸酯

• 产品号: A9043
• CAS号: 76931-93-6
• 分子式: C8H9NO5S
• 分子量: 231.22576
• 纯 度: ≥95% (TLC)

产品别名

• 标题: S-Acetylthioglycolic acid N-hydroxysuccinimide ester
• IUPAC标准名: 2,5-dioxopyrrolidin-1-yl 2-(acetylsulfanyl)acetate
• IUPAC传统名: 2,5-dioxopyrrolidin-1-yl 2-(acetylsulfanyl)acetate
• 别名: N-Succinimidyl S-acetylthioglycolate; N-琥珀酰亚胺基-S-乙酰硫基乙酸酯; S-乙酰硫基乙酸琥珀酰亚胺酯; N-Succinimidyl (acetylthio)acetate; S-Acetylthioglycolic acid NHS ester; N-丁二酸S-乙酰基巯基乙二醇酯

产品登记号

• CAS号: 76931-93-6
• MDL号: MFCD00036891
• PubChem SID: 24891221
• Beilstein号: 7815491

产品性质

• Empirical Formula (Hill Notation): C8H9NO5S
• 纯度: ≥95% (TLC)
• 外观: powder
• 溶解度: acetonitrile: soluble50 mg/mL
• 溶解度: DMF: soluble
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Thiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, couples initially to a molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with 0.05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
Other Notes
Note that the ester couples very efficiently to primary amines compared to other thiolating reagents. In addition, this reagent will neutralize original amine positive charge.

详细说明 (简体中文)

Application
伯胺的硫醇化试剂；在温和条件下可使硫醇去保护。通常在 pH 为 7.5 时引发耦合反应，通过酰胺键生成含伯胺的分子。在中性 pH 时可与 0.05M 羟胺发生去保护反应。用于制备酶免疫交联剂和半抗原载体分子偶联物。
Other Notes
注意，与其他硫醇化试剂相比，对伯胺的酯偶合作用非常有效。此外，这种试剂可以中和伯胺的正电荷。