Penta-O-galloyl-β-D-glucose hydrate

• 产品号: G7548
• CAS号: 14937-32-7(anhydrous)
• 分子式: C41H32O26
• 分子量: 940.67718
• 纯 度: ≥96% (HPLC)

产品别名

• 标题: Penta-O-galloyl-β-D-glucose hydrate
• IUPAC标准名: [(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis(3,4,5-trihydroxybenzoyloxy)oxan-2-yl]methyl 3,4,5-trihydroxybenzoate
• IUPAC传统名: 1,2,3,4,6-pentagalloylglucose
• 别名: Penta-O-galloyl-beta-D-glucose; PGG; 1,2,3,4,6-pentakis(3,4,5-trihydroxybenzoate)-b-D-Glucopyranose; Penta-1,2,3,4,6-O-galloyl-b-D-glucose; 1,2,3,4,6-Penta-O-galloyl-b-D-glucopyranose; Gallic acid, pentaester with b-D-glucopyranose; Glucopyranose, pentagallate, b-D

产品登记号

• MDL号: MFCD03788860
• CAS号: 14937-32-7(anhydrous)

产品性质

• Empirical Formula (Hill Notation): C41H32O26 · xH2O
• 纯度: ≥96% (HPLC)
• 外观: light brown powder
• 溶解度: DMSO: ≥20 mg/mL
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
PGG induces predominantly (caspase dependent) apoptosis in DU145 and LNCaP cells, while inducing autophagy in more resistant PC3 and TRAMP-C2 cells. It appears that PGG targeted signaling downstream of rather than the mTOR itself. Polyphenolic pyranoses were reported (J Biol Chem. 2010, 285 (11), 7892-902) to inhibit the plasminogen activator inhibitor type 1 (PAI-1).

详细说明 (简体中文)

Biochem/physiol Actions
PGG induces predominantly (caspase dependent) apoptosis in DU145 and LNCaP cells, while inducing autophagy in more resistant PC3 and TRAMP-C2 cells. It appears that PGG targeted signaling downstream of rather than the mTOR itself. Polyphenolic pyranoses were reported (J Biol Chem. 2010, 285 (11), 7892-902) to inhibit the plasminogen activator inhibitor type 1 (PAI-1).