YS-49 monohydrate

• 产品号: Y1521
• CAS号: 132836-42-1(anhydrous)
• 分子式: C20H22BrNO3
• 分子量: 404.29758
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: YS-49 monohydrate
• IUPAC标准名: 1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrate hydrobromide
• IUPAC传统名: 1-(naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrate hydrobromide
• 别名: 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate

产品登记号

• CAS号: 132836-42-1(anhydrous)
• MDL号: MFCD16875442

产品性质

• Empirical Formula (Hill Notation): C20H19NO2 · HBr · H2O
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: H2O: >10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 危险公开号: 22-50
• 安全公开号: 61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.

详细说明 (简体中文)

Biochem/physiol Actions
YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.