Razoxane

• 产品号: R8657
• CAS号: 21416-67-1
• 分子式: C11H16N4O4
• 分子量: 268.26914
• 纯 度: >98% (HPLC)

产品别名

• 标题: Razoxane
• IUPAC标准名: 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
• IUPAC传统名: razoxane
• 别名: Troxozone; ICI 59118; (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; Tepirone; ICRF 159; (±)-1,2-Bis(3,5-dioxopiperazinyl)propane; 1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4′-Propylenebis(2,6-piperazinedione); NSC 129943; Razoxin

产品登记号

• MDL号: MFCD00430424
• CAS号: 21416-67-1
• EC号: 244-379-2

产品性质

• Empirical Formula (Hill Notation): C11H16N4O4
• 纯度: >98% (HPLC)
• 外观: solid
• 溶解度: DMSO: soluble40 mg/mL
• RTECS编号: TL6389900
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

详细说明 (简体中文)

Biochem/physiol Actions
Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.