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N-Arachidonylmaleimide_分子结构_CAS_876305-42-9)
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N-Arachidonylmaleimide

产品号 A2984 公司名称 Sigma Aldrich
CAS号 876305-42-9 公司网站 http://www.sigmaaldrich.com
分子式 C24H35NO2 电 话 1-800-521-8956
分子量 369.5402 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 under inert gas Chembase数据库ID: 154504

产品价格信息

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产品别名

标题
N-Arachidonylmaleimide
IUPAC标准名
1-(icosa-5,8,11,14-tetraen-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
IUPAC传统名
1-(icosa-5,8,11,14-tetraen-1-yl)pyrrole-2,5-dione

产品登记号

CAS号 876305-42-9
MDL号 MFCD11521506

产品性质

Empirical Formula (Hill Notation) C24H35NO2
纯度 ≥98% (HPLC)
外观 solid
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H317
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
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GHS警示性声明 P280
危险公开号 43
安全公开号 36/37
保存条件 under inert gas
保存温度 -20°C
德国WGK号 1

产品详细信息

详细说明 (English)
Biochem/physiol Actions
N-Arachidonylmaleidmide, NAM, is a potent irreversible inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes.
详细说明 (简体中文)
Biochem/physiol Actions
N-Arachidonylmaleidmide, NAM, is a potent irreversible inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes.

参考文献