1-(icosa-5,8,11,14-tetraen-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione

• ChemBase编号: 154504
• 分子式: C24H35NO2
• 平均质量: 369.5402
• 单一同位素质量: 369.26677937
• SMILES: CCCCC/C=C/C/C=C/C/C=C/C/C=C/CCCCN1C(=O)C=CC1=O
• Canonical SMILES: CCCCC/C=C/C/C=C/C/C=C/C/C=C/CCCCN1C(=O)C=CC1=O
• InChI: InChI=1S/C24H35NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-23(26)20-21-24(25)27/h6-7,9-10,12-13,15-16,20-21H,2-5,8,11,14,17-19,22H2,1H3
• InChIKey: GZNZRHSGGQUYAP-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 1-(icosa-5,8,11,14-tetraen-1-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
• IUPAC传统名: 1-(icosa-5,8,11,14-tetraen-1-yl)pyrrole-2,5-dione
• 别名: N-Arachidonylmaleimide

登记号

• CAS号: 876305-42-9
• MDL号: MFCD11521506
• PubChem SID: 162248643
• PubChem CID: 71311881

理论计算性质

• 质子受体: 2
• 质子供体: 0
• LogD (pH = 5.5): 6.577084
• LogD (pH = 7.4): 6.577084
• Log P: 6.577084
• 摩尔折射率: 120.2041 cm^3
• 极化性: 44.314014 Å^3
• 极化表面积: 37.38 Å^2
• 可自由旋转的化学键: 15
• 里宾斯基五规则: false

分子性质

理化性质

• 外观: solid

安全信息

• 保存条件: under inert gas
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 德国WGK号: 1
• 危险公开号: 43
• 安全公开号: 36/37
• GHS危险品标识: GHS07
• GHS警示词: Warning
• GHS危险声明: H317
• GHS警示性声明: P280
• 保存温度: -20°C

产品相关信息

• 纯度: ≥98% (HPLC)
• Empirical Formula (Hill Notation): C24H35NO2

详细说明

Sigma Aldrich - A2984

Biochem/physiol Actions
N-Arachidonylmaleidmide, NAM, is a potent irreversible inhibitor of MAGL, the enzyme predominantly responsible for the degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG). Anandamide and 2-AG are the two endogenous endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Anandamide is predominantly metabolized by fatty acid amide hydrolase (FAAH), whereas monoacylglycerol lipase (MAGL) is thought to be the enzyme primarily responsible for the degradation of 2-AG. It is difficult to separate the activities of the two because most currently available inhibitors of MAGL are not selective, and also inhibit FAAH or other enzymes.