KM11060

• 产品号: K1519
• CAS号: 774549-97-2
• 分子式: C19H17Cl2N3O2S
• 分子量: 422.32818
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: KM11060
• IUPAC标准名: 7-chloro-4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]quinoline
• IUPAC传统名: 7-chloro-4-[4-(4-chlorobenzenesulfonyl)piperazin-1-yl]quinoline
• 别名: 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline

产品登记号

• CAS号: 774549-97-2
• MDL号: MFCD01524977

产品性质

• Empirical Formula (Hill Notation): C19H17Cl2N3O2S
• 纯度: ≥98% (HPLC)
• 外观: powder
• 溶解度: DMSO: >10 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25
• 安全公开号: 45
• 保存温度: room temp
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.

详细说明 (English)

Biochem/physiol Actions
KM11060 is a mutated F508del cystic fibrosis transmembrane conductance regulator (CFTR) corrector. The most common mutation (~90%) in the CFTR gene is a deletion of phenylalanine 508 (F508del). The mutation impairs folding, trafficking, membrane stability, and channel gating leading to reduced CFTR expression and chloride conductance in the apical membrane and other abnormalities. KM11060 is an analog of sildenafil, which restores a function of the F508del mutated CFTR chloride channel. KM11060 appears to be more potent than sildenafil, forskolin, and genistein.