AMN082

• 产品号: A6605
• CAS号: 97075-46-2
• 分子式: C28H30Cl2N2
• 分子量: 465.4572
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: AMN082
• IUPAC标准名: (diphenylmethyl)({2-[(diphenylmethyl)amino]ethyl})amine dihydrochloride
• IUPAC传统名: (diphenylmethyl)({2-[(diphenylmethyl)amino]ethyl})amine dihydrochloride
• 别名: N,N′-Dibenzhydrylethane-1,2-diamine dihydrochloride

产品登记号

• PubChem SID: 24891112
• CAS号: 97075-46-2
• MDL号: MFCD08702723

产品性质

• Empirical Formula (Hill Notation): C28H28N2 · 2HCl
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 溶解度: DMSO: ≥5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H400
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P273
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 22-50
• 安全公开号: 61
• 保存条件: desiccated
• 保存温度: -20°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
AMN082 is a selective allosteric mGluR 7 receptor agonist and has been used to study the role of this glutamate receptor type in the medial prefrontal cortex in mice. AMN082 inhibits forskolin-stimulated cAMP accumulation, and stimulates not only GTPγS binding but also the release of stress hormones.
Biochem/physiol Actions
AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC50 = 64 nM) and stimulates GTPγS binding (EC50 = 290 nM) similar to L-AP4 and greater than L-glutamate. Thus, AMN082 is a "full agonist" and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR′s up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.

详细说明 (简体中文)

Application
AMN082 is a selective allosteric mGluR 7 receptor agonist and has been used to study the role of this glutamate receptor type in the medial prefrontal cortex in mice. AMN082 inhibits forskolin-stimulated cAMP accumulation, and stimulates not only GTPγS binding but also the release of stress hormones.
Biochem/physiol Actions
AMN082 is a selective allosteric mGluR 7 receptor agonist and first selective pharmacological tool for mGluR7. AMN082 inhibits forskolin-stimulated cAMP accumulation (EC50 = 64 nM) and stimulates GTPγS binding (EC50 = 290 nM) similar to L-AP4 and greater than L-glutamate. Thus, AMN082 is a "full agonist" and acts at an allosteric site in the transmembrane domain of mGluR7. AMN082 has no effects at other mGluR′s up to 10 μM and stimulates release of stress hormones (corticosterone and ACTH) and is orally active and brain penetrable.