Ciproxifan hydrochloride

• 产品号: C6492
• CAS号: 1049741-81-2
• 分子式: C16H19ClN2O2
• 分子量: 306.78726
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Ciproxifan hydrochloride
• IUPAC标准名: 4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole hydrochloride
• IUPAC传统名: 4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole hydrochloride
• 别名: Cyclopropyl[4-[3-(1H-imidazol-4-yl)propoxyl]phenyl]-methanone hydrochloride

产品登记号

• PubChem SID: 24724449
• MDL号: MFCD08705321
• CAS号: 1049741-81-2

产品性质

• Empirical Formula (Hill Notation): C16H18N2O2 · HCl
• 纯度: ≥98% (HPLC)
• 外观: off-white solid
• 溶解度: DMSO: soluble30 mg/mL
• 溶解度: water, high purity: soluble30 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Gloves
• 危险公开号: 22
• 保存条件: desiccated
• 保存条件: under inert gas
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.

详细说明 (简体中文)

Biochem/physiol Actions
Ciproxifan belongs to a novel chemical series of histamine H3-receptor antagonists. In vitro, it behaved as a competitive antagonist at the H3 autoreceptor controlling 3H histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with 125I-iodoproxyfan. Ciproxifan appears to be an orally bioavailable, extremely potent and selective H3-receptor antagonist whose vigilance- and attention-promoting effects are promising for therapeutic applications in aging disorders.