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聚合物键合型 2-氯代三苯甲基氯_分子结构_CAS_)
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聚合物键合型 2-氯代三苯甲基氯

产品号 532304 公司名称 Sigma Aldrich
CAS号 公司网站 http://www.sigmaaldrich.com
分子式 C19H14Cl2 电 话 1-800-521-8956
分子量 313.22046 传 真
纯 度 电子邮件
保 存 Chembase数据库ID: 147969

产品价格信息

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产品别名

标题
2-Chlorotrityl chloride, polymer-bound
IUPAC标准名
1-chloro-2-(chlorodiphenylmethyl)benzene
IUPAC传统名
1-chloro-2-(chlorodiphenylmethyl)benzene
别名
2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene

产品登记号

MDL号 MFCD00040399
Beilstein号 1983914
PubChem SID 24877877

产品性质

标签扩展内容 1.0-1.5 mmol/g
颗粒大小 100-200 mesh
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H315-H319-H335
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P261-P305 + P351 + P338
危险公开号 36/37/38
安全公开号 26
德国WGK号 3

产品详细信息

详细说明 (English)
Packaging
1, 5 g in glass bottle
Application

• Acid labile resin used in Fmoc-based solid phase peptide synthesis.
• Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
• 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
• This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences. Use:
• Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
• Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
• Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
• If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
详细说明 (简体中文)
包装
1, 5 g in glass bottle
Application

• Acid labile resin used in Fmoc-based solid phase peptide synthesis.
• Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
• 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
• This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences. Use:
• Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
• Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
• Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
• If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.

参考文献