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42074-68-0 分子结构
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1-chloro-2-(chlorodiphenylmethyl)benzene

ChemBase编号:147969
分子式:C19H14Cl2
平均质量:313.22046
单一同位素质量:312.04725581
SMILES和InChIs

SMILES:
c1ccc(cc1)C(c1ccccc1)(c1ccccc1Cl)Cl
Canonical SMILES:
Clc1ccccc1C(c1ccccc1)(c1ccccc1)Cl
InChI:
InChI=1S/C19H14Cl2/c20-18-14-8-7-13-17(18)19(21,15-9-3-1-4-10-15)16-11-5-2-6-12-16/h1-14H
InChIKey:
JFLSOKIMYBSASW-UHFFFAOYSA-N

引用这个纪录

CBID:147969 http://www.chembase.cn/molecule-147969.html

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名称和登记号

名称和登记号

名称 登记号
IUPAC标准名
1-chloro-2-(chlorodiphenylmethyl)benzene
IUPAC传统名
1-chloro-2-(chlorodiphenylmethyl)benzene
别名
聚合物键合型 2-氯代三苯甲基氯
氯(2-氯苯基)二苯甲烷
2-氯代三苯甲基氯
聚合物键合型 2-氯代三苯甲基氯
StratoSpheres™ PL-Cl-Trt-Cl(2-氯三苯甲基氯)树脂
2,α-Dichlorobenzhydryl-polystyrene crosslinked with divinylbenzene
2-Chlorotrityl chloride, polymer-bound
Chloro(2-chlorophenyl)diphenylmethane
2-Chlorotrityl chloride
2-Chlorotrityl chloride, polymer-bound
StratoSpheres™ PL-Cl-Trt-Cl (2-chlorotrityl Cl) resin
1-Chloro-2-(chlorodiphenylmethyl)benzene
2-Chlorophenyldiphenylchloromethane
2-Chlorophenyldiphenylmethyl Chloride
Diphenyl-2-chlorophenylmethyl Chloride
o-Chlorotriphenylchloromethane
2-Chlorotrityl Chloride
CAS号
42074-68-0
EC号
255-647-3
MDL号
MFCD00040399
Beilstein号
1983914
PubChem SID
24886538
24877874
24879431
24856098
24856099
162242149
24877876
24877877
PubChem CID
94524

理论计算性质

理论计算性质

JChem
质子受体 质子供体
LogD (pH = 5.5) 6.5970144  LogD (pH = 7.4) 6.5970144 
Log P 6.5970144  摩尔折射率 91.1673 cm3
极化性 35.0477 Å3 极化表面积 0.0 Å2
可自由旋转的化学键 里宾斯基五规则 false 

分子性质

分子性质

理化性质 安全信息 产品相关信息 生物活性(PubChem)
熔点
130-135 °C expand 查看数据来源
欧盟危险性物质标志
刺激性(Irritant) 刺激性(Irritant) (Xi) expand 查看数据来源
MSDS下载
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
下载链接 expand 查看数据来源
德国WGK号
3 expand 查看数据来源
危险公开号
36/37/38 expand 查看数据来源
安全公开号
26 expand 查看数据来源
GHS危险品标识
GHS07 expand 查看数据来源
GHS警示词
Warning expand 查看数据来源
GHS危险声明
H315-H319-H335 expand 查看数据来源
GHS警示性声明
P261-P305 + P351 + P338 expand 查看数据来源
个人保护装置
dust mask type N95 (US), Eyeshields, Gloves expand 查看数据来源
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter expand 查看数据来源
保存温度
2-8°C expand 查看数据来源
纯度
≥97.0% (AT) expand 查看数据来源
颗粒大小
100-200 mesh expand 查看数据来源
100-300 mesh expand 查看数据来源
200-400 mesh expand 查看数据来源
50-100 mesh expand 查看数据来源
质检报告
下载链接 expand 查看数据来源
标签扩展内容
~1.6 mmol/g Cl loading expand 查看数据来源
0.3-0.8 mmol/g Cl loading expand 查看数据来源
1.0-1.5 mmol/g expand 查看数据来源
1.0-1.5 mmol/g Cl loading expand 查看数据来源
1.0-1.6 mmol/g loading expand 查看数据来源
1.5 mmol/g loading expand 查看数据来源
基质
crosslinked with 1% DVB expand 查看数据来源
polystyrene, crosslinked with 1% DVB expand 查看数据来源
Crosslinking
1 % cross-linked expand 查看数据来源
2 % cross-linked expand 查看数据来源
Empirical Formula (Hill Notation)
C19H14Cl2 expand 查看数据来源

详细说明

详细说明

Sigma Aldrich Sigma Aldrich TRC TRC
Sigma Aldrich -  26569 external link
Other Notes
羧酸的基团保护试剂,形成轻度裂解的酯。1
包装
10 g in poly bottle
Sigma Aldrich -  554790 external link
包装
5 g in glass bottle
法律信息
StratoSpheres 商标 Agilent Technologies, Inc.
Sigma Aldrich -  532282 external link
包装
5 g in glass bottle
Application

• Acid labile resin used in Fmoc-based solid phase peptide synthesis.
• Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
• 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
• This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences. Use:
• Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
• Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
• Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
• If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
Sigma Aldrich -  532304 external link
包装
1, 5 g in glass bottle
Application

• Acid labile resin used in Fmoc-based solid phase peptide synthesis.
• Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
• 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
• This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences. Use:
• Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
• Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
• Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
• If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
Sigma Aldrich -  26568 external link
Other Notes
用于肽的 FMOC-氨基酸固相合成的载体。1,2,3
包装
5 g in glass bottle
Application

• Acid labile resin used in Fmoc-based solid phase peptide synthesis.
• Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
• 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
• This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences. Use:
• Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
• Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
• Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
• If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
Sigma Aldrich -  532290 external link
包装
1, 5 g in glass bottle
Application

• Acid labile resin used in Fmoc-based solid phase peptide synthesis.
• Mild acidic cleavage conditions lead to the release of the peptide acid where fully protected peptides can be released if desired.
• 2-Chlorotrityl chloride resins prevent racemization of the first amino acid and are thus very useful when racemic mixtures are forming (common with residues such as His or Cys).
• This resin also prevents diketopiperazide formation, which can be an issue with proline C-terminal peptide sequences. Use:
• Attachment of the first amino acid residue is effected by stirring the resin, the protected amino acid, and excess diisopropylethylamine (DIEA) in dichloromethane.
• Cleavage of the final protected peptide fragment is achieved under very mild conditions using either acetic acid/trifluoroethanol (TFE)/dichloromethane (1:1:8; v/v/v), hexafluoroisopropanol (HFIP)/dichloromethane (1:4; v/v) or simply 0.5% trifluoroacetic acid/dichloromethane (v/v).
• Higher concentrations of TFA can be used if retention of peptide side chaing protecting groups is unimportant. Note that trityl chloride is moisture-sensitive, and, therefore, should be stored and handled appropriately.
• If the resin becomes deactivated, treatment with acetyl chloride or SOCl2 in toluene before use is recommended to restore its activity.
Toronto Research Chemicals -  C422260 external link
2-Chlorotrityl Chloride is used in convergent peptide synthesis. 2-Chlorotrityl Chloride is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase.

参考文献

参考文献

供应商提供 Google Scholar IconGoogle Scholar PubMed iconPubMed Google Books IconGoogle Books
  • Ruda, G.F. et al.: ChemMedChem, 6, 309 (2011)
  • Athanassopoulos, P. et al.: Tetrahed. Lett., 36, 5645 (2011)
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专利

专利

PubChem iconPubChem Patent Google Patent Search IconGoogle Patent

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