α-Amanitin

• 产品号: A2263
• CAS号: 23109-05-9
• 分子式: C39H54N10O14S
• 分子量: 918.96966
• 纯 度: ≥90% (HPLC)

产品别名

• 标题: α-Amanitin
• IUPAC标准名: 2-[34-(butan-2-yl)-13-(3,4-dihydroxybutan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27λ^4-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0^6,^1^0.0^1^8,^2^6.0^1^9,^2^4]nonatriaconta-18(26),19,21,23-tetraen-4-yl]acetamide
• IUPAC传统名: α-amanitin

产品登记号

• CAS号: 23109-05-9
• Beilstein号: 1071138
• PubChem SID: 24890639
• EC号: 245-432-2
• MDL号: MFCD00215842

产品性质

• 生物来源: from Amanita phalloides
• 纯度: ≥90% (HPLC)
• 紫外吸收波长: ε1M/310 nm, H2O 13,500
• 外观: white to light yellow powder
• 熔点: 254-255 °C(lit.)
• 溶解度: H2O: soluble1.0 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300-H310-H330-H373
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• 个人保护装置: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
• GHS警示性声明: P260-P264-P280-P284-P301 + P310-P302 + P350
• RID/ADR: UN 3462 6.1/PG 2
• 危险公开号: 26/27/28-33
• RTECS编号: BD6195000
• 安全公开号: 36/37/39-45
• 保存温度: -20°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 3462
• 联合国危险货物包装类别(PG): 2
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Amino Acid Sequence
Asn-Hyp-Hyi-Trp-Gly-Ile-Gly-Cys [Bridge: 4-8]
Caution
When stored frozen in the dark, retained samples were found to be greater than 99% by HPLC after two years.
Reconstitution
Store a 1 mg/ml aqueous stock solution frozen at -20°C. It does not degrade with repeated freeze-thaw cycles. Dilute into the appropriate buffer immediately prior to use. Product is destroyed by concentrated acid or base.
Biochem/physiol Actions
The major toxic constituent of the mushroom, Amanita phalloides, inhibits eukaryotic RNA polymerase II and III, but does not inhibit RNA polymerase I or bacterial RNA polymerase. Inhibits mammalian protein synthesis.