UA62784

• 产品号: D9688
• CAS号: 313367-92-9
• 分子式: C23H15NO3
• 分子量: 353.3701
• 纯 度: ≥95% (SDS-PAGE)

产品别名

• 标题: UA62784
• IUPAC标准名: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one
• IUPAC传统名: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]fluoren-9-one
• 别名: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one

产品登记号

• CAS号: 313367-92-9
• MDL号: MFCD00489199

产品性质

• 杂质: endotoxin, tested
• Mol. Weight: glycosylated form mol wt 75-90 kDa by SDS-PAGE (reducing)
• 纯度: ≥95% (SDS-PAGE)
• 基因表达载体: expressed in NSO cells
• 适用性: cell culture tested
• 相关基因信息: human ... TNFRSF10C(8794)
• 外观: lyophilized powder
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• 保存温度: -20°C

产品详细信息

详细说明 (English)

Analysis Note
Activity is measured by its ability to inhibit apoptosis of mouse L929 cells treated with 20 ng/mL recombinant human TRAIL or 12 ng/mL cross-linked recombinant human TRAIL.
Biochem/physiol Actions
Glycosyl-phosphatidylinositol-linked membrane protein that is a member of the TNF receptor family. Acts as a decoy receptor that inhibits TRAIL signaling.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin.