4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one

• ChemBase编号: 134081
• 分子式: C23H15NO3
• 平均质量: 353.3701
• 单一同位素质量: 353.10519335
• SMILES: COc1ccc(cc1)c1cnc(o1)c1cccc2c1c1ccccc1C2=O
• Canonical SMILES: COc1ccc(cc1)c1cnc(o1)c1cccc2c1c1ccccc1C2=O
• InChI: InChI=1S/C23H15NO3/c1-26-15-11-9-14(10-12-15)20-13-24-23(27-20)19-8-4-7-18-21(19)16-5-2-3-6-17(16)22(18)25/h2-13H,1H3
• InChIKey: SVICLWPFAQYZLX-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one
• IUPAC传统名: 4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]fluoren-9-one
• 别名: 4-[5-(4-Methoxyphenyl)-2-oxazolyl]-9H-Fluoren-9-one; UA62784

登记号

• CAS号: 313367-92-9
• MDL号: MFCD00489199
• PubChem SID: 162228358
• PubChem CID: 3383533

理论计算性质

• 质子受体: 3
• 质子供体: 0
• LogD (pH = 5.5): 4.4827905
• LogD (pH = 7.4): 4.4827952
• Log P: 4.4827952
• 摩尔折射率: 112.9996 cm^3
• 极化性: 42.452343 Å^3
• 极化表面积: 52.33 Å^2
• 可自由旋转的化学键: 3
• 里宾斯基五规则: true

分子性质

理化性质

• 溶解度: DMSO: >2 mg/mL
• 外观: lyophilized powder; yellow powder

安全信息

• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• GHS危险品标识: GHS07
• GHS警示词: Warning
• GHS危险声明: H302
• 保存温度: -20°C; 2-8°C

药理学性质

• 相关基因信息: human ... TNFRSF10C(8794)

产品相关信息

• 纯度: ≥95% (SDS-PAGE); ≥98% (HPLC)
• 适用性: cell culture tested
• 杂质: endotoxin, tested
• 基因表达载体: expressed in NSO cells
• Mol. Weight: glycosylated form mol wt 75-90 kDa by SDS-PAGE (reducing)
• Empirical Formula (Hill Notation): C23H15NO3

详细说明

Sigma Aldrich - D9688

Analysis Note
Activity is measured by its ability to inhibit apoptosis of mouse L929 cells treated with 20 ng/mL recombinant human TRAIL or 12 ng/mL cross-linked recombinant human TRAIL.
Biochem/physiol Actions
Glycosyl-phosphatidylinositol-linked membrane protein that is a member of the TNF receptor family. Acts as a decoy receptor that inhibits TRAIL signaling.
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5.0 mg bovine serum albumin.

Sigma Aldrich - U3385

Biochem/physiol Actions
UA62784 is a specific inhibitor of centromere protein E (CENPE) kinesin-like protein; mitotic inhibitor. CENP-E is a kinesin-like motor protein that localizes to the kinetochore during mitosis and is essential for bipolar spindle formation. UA62784 is a novel specific inhibitor of CENP-E, which likely binds within the motor domain of CENP-E. UA62784 causes reversible cell cycle arrest in mitosis before metaphase, which leads to apoptosis. The compound is not interacting with microtubules directly.