Ribostamycin sulfate salt

• 产品号: R2255
• CAS号: 53797-35-6
• 分子式: C17H36N4O14S
• 分子量: 552.55114

产品别名

• 标题: Ribostamycin sulfate salt
• IUPAC标准名: (2S,3R,4S,5S,6S)-5-amino-2-(aminomethyl)-6-{[(1S,2S,3R,4S,6R)-4,6-diamino-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol; sulfuric acid
• IUPAC传统名: (2S,3R,4S,5S,6S)-5-amino-2-(aminomethyl)-6-{[(1S,2S,3R,4S,6R)-4,6-diamino-2-{[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-3-hydroxycyclohexyl]oxy}oxane-3,4-diol; sulfuric acid

产品登记号

• CAS号: 53797-35-6
• EC号: 258-783-1
• MDL号: MFCD00057496

产品性质

• GHS警示词: Danger
• GHS危险声明: H312-H332-H360
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 个人保护装置: Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
• GHS警示性声明: P201-P280-P308 + P313
• 危险公开号: 61-20/21/22
• RTECS编号: WK2300000
• 安全公开号: 53-22-36/37/39-45
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Application
Ribostamycin is a broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus. It is used in pharmacokinetic and nephrotoxicity studies1,2.
Biochem/physiol Actions
Aminoglycosides, such as ribostamycin, bind to the bacterial 30S and 50S ribosomal subunit, which inhibits the translocation of the peptidyl-tRNA from the A-site to the P-site. This causes misreading of mRNA which makes bacteria unable to make essential proteins3. It also inhibits the chaperone activity of protein disulfide isomerase (PDI).