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亚精胺

产品号 S4139 公司名称 Sigma Aldrich
CAS号 124-20-9 公司网站 http://www.sigmaaldrich.com
分子式 C7H19N3 电 话 1-800-521-8956
分子量 145.24586 传 真
纯 度 ≥98% (GC) 电子邮件
保 存 Chembase数据库ID: 3231

产品价格信息

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产品别名

标题
Spermidine
IUPAC标准名
(4-aminobutyl)(3-aminopropyl)amine
IUPAC传统名
spermidine
别名
N-(3-氨基丙基)-1,4-丁二胺
1,8-二氨基-4-氮杂辛烷

产品登记号

Beilstein号 1698591
PubChem SID 24899590
EC号 204-689-0
MDL号 MFCD00008229
CAS号 124-20-9

产品性质

纯度 ≥98% (GC)
适用性 suitable for cell culture
相关基因信息 rat ... Ppm1a(24666)
密度 0.925 g/mL at 25 °C(lit.)
闪点 112 °C
闪点 233.6 °F
折射率 n20/D 1.479(lit.)
GHS危险品标识 GHS05
GHS警示词 Danger
GHS危险声明 H314
欧盟危险性物质标志 腐蚀性(Corrosive) 腐蚀性(Corrosive) (C)
个人保护装置 Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
GHS警示性声明 P280-P305 + P351 + P338-P310
RID/ADR UN 2735 8/PG 2
危险公开号 34
RTECS编号 EJ7000000
安全公开号 26-36/37/39-45
保存温度 2-8°C
联合国危险货物等级 8
联合国危险货物编号 2735
联合国危险货物包装类别(PG) 2
德国WGK号 3

产品详细信息

详细说明 (简体中文)
Caution
如果需要无菌溶液,则应采用无菌过滤而非高压灭菌。时间一长,亚精胺将发生脱氨基作用;溶液应采用冷冻保存。通常需要配制新溶液。
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine together with putrescine and spermine compose a family of biogenic polyamines (polycations) that are required for the survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycan, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols. Spermidine Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.

参考文献