(4-aminobutyl)(3-aminopropyl)amine

• ChemBase编号: 3231
• 分子式: C7H19N3
• 平均质量: 145.24586
• 单一同位素质量: 145.15789762
• SMILES: NCCCCNCCCN
• Canonical SMILES: NCCCNCCCCN
• InChI: InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• InChIKey: ATHGHQPFGPMSJY-UHFFFAOYSA-N

名称和登记号

名称

• IUPAC标准名: (4-aminobutyl)(3-aminopropyl)amine
• IUPAC传统名: spermidine
• 别名: 1,8-二氨基-4-氮杂辛烷; N-(3-氨基丙基)-1,4-丁二胺; 亚精胺; N-(3-Aminopropyl)-1,4-butane-diamine; 1,8-Diamino-4-azaoctane; 4-Azaoctane-1,8-diamine; N-(3-Aminopropyl)-1,4-butanediamine; N-(3-Aminopropyl)-1,4-diaminobutane; N-(3-aminopropyl)butane-1,4-diamine; Spermidin; 1,5,10-Triazadecane; Spermidine; Spermidine; Additive Screening Solution 30/Fluka kit no 78374; Spermidine solution; Spermidine 0.1 M solution; N-[3-Aminopropyl]-1,4-butanediamine; N1-(3-Aminopropyl)-1,4-butanediamine; N-(3-Aminopropyl)-4-aminobutylamine; N-(4-Aminobutyl)-1,3-diaminopropane

登记号

• CAS号: 124-20-9
• EC号: 204-689-0
• MDL号: MFCD00008229
• Beilstein号: 1698591
• 默克索引号: 148742
• PubChem SID: 24899590; 24888389; 24899529; 24899434; 24845842; 160966674; 24888388; 46506086
• PubChem CID: 1102
• CHEBI ID: 16610
• CHEMBL: 19612
• Chemspider ID: 1071
• DrugBank ID: DB03566
• Gmelin ID: 454510
• IUPHAR配体索引: 2390
• KEGG ID: C00315
• 医学主题词(MeSH): Spermidine
• 维基百科标题: Spermidine

理论计算性质

JChem

• 质子受体: 3
• 质子供体: 3
• LogD (pH = 5.5): -10.062785
• LogD (pH = 7.4): -7.799325
• Log P: -1.1495639
• 摩尔折射率: 44.9684 cm^3
• 极化性: 18.22489 Å^3
• 极化表面积: 64.07 Å^2
• 可自由旋转的化学键: 7
• 里宾斯基五规则: true

ALOGPS 2.1

• Log P: -0.62
• LOG S: -0.65
• 溶解度: 3.27e+01 g/l

分子性质

理化性质

• 溶解度: 145 g L^-1 (at 20 °C) in water; H2O: soluble1 M at 20 °C, clear, colorless
• 外观: Colourless liquid
• 熔点: 22 - 25°C; 22-25 °C; 22-25°C; 23-25 °C
• 沸点: 128-130°C; 128-130°C/14mm
• 闪点: > 109°C; >110°C(230°F); 112 °C; 233.6 °F
• 密度: 0.925; 0.925 g/mL; 0.925 g/mL at 25 °C(lit.); 1.00 g/mL at 20 °C; 925 mg mL^-1
• 折射率: 1.479; 1.4790; n20/D 1.479(lit.)
• 分配系数: -0.504
• 紫外吸收波长: 260 nm; λ: 260 nm Amax: 0.1; λ: 280 nm Amax: 0.05
• 气味: Ichtyal, ammoniacal
• 吸光度: 0.1
• pH值: 12.0-13.5 (25 °C, 1 M in H2O)

安全信息

• 保存条件: 2-8°C, Desiccate
• 保存注意事项: Air Sensitive
• RTECS编号: EJ7000000
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• 联合国危险货物编号: 1760; 2735; UN2735
• 德国WGK号: 2; 3
• 联合国危险货物等级: 8
• 联合国危险货物包装类别(PG): 2; II; III
• 澳大利亚Hazchem: 2X
• 危险公开号: 34; R:34-36/37/38; r34
• 安全公开号: 20-23-26-36/37/39-45; 26-36/37/39-45; S:26-27/28-36/37/39-46-64; s26, s36/37/39
• 欧盟危险货物分类: C9
• 欧盟危险识别号(EUHIN): 8B
• 美国ERG指导号: 154
• TSCA收录: 是
• GHS危险品标识: gHS corrosion; GHS05; GHS07
• GHS警示词: DANGER; Danger; Warning
• GHS危险声明: 314; H314; H314-H318; H315-H319
• GHS警示性声明: 280, 305+351+338, 310; P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A; P280-P305 + P351 + P338-P310; P305 + P351 + P338
• 个人保护装置: Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter; Faceshields, Gloves, Goggles
• RID/ADR: UN 2735 8/PG 2
• 保存温度: 2-8°C

药理学性质

• 相关基因信息: mouse ... Odc1(18263)rat ... Ppm1a(24666); rat ... Ppm1a(24666)

产品相关信息

• 纯度: ~99%; ≥98%; ≥98% (GC); ≥99.0% (GC); ≥99.5% (GC); 99%
• 级别: for molecular biology
• 适用性: suitable for cell culture
• 杂质: ≤0.2% spermine; DNases, none detected; insoluble matter, passes filter test; phosphatases, none detected; proteases, none detected; RNases, none detected
• 痕量阳离子: Al: ≤5 mg/kg; As: ≤0.1 mg/kg; Ba: ≤5 mg/kg; Bi: ≤5 mg/kg; Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Li: ≤5 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Mo: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Sr: ≤5 mg/kg; Zn: ≤5 mg/kg
• 痕量阴离子: chloride (Cl-): ≤50 mg/kg; sulfate (SO42-): ≤50 mg/kg
• Foreign Activity: DNase, RNase, and protease, none detected
• λ: 1 M in H2O
• 产品线: BioUltra
• 线性分子式: NH2(CH2)3NH(CH2)4NH2

详细说明

MP Biomedicals - 02152068

Free Base
Purity: ~99%
Density: 0.925 g/mL

MP Biomedicals - 02194852

(N-[3-Aminopropyl]-1,4-butanediamine) Molecular Biology Reagent Free Base Purity: ~99% Promotes T4 polynucleotide kinase activity.

DrugBank - DB03566

• Drug Groups: experimental
• Description: Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
• External Links: Wikipedia

Sigma Aldrich - S0266

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Sigma Aldrich - S2626

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
包装
1, 5, 25 g in glass bottle
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Sigma Aldrich - 85558

Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
Other Notes
In first strand cDNA synthesis1; Effect on endonuclease inhibition by agarose contaminants2
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Sigma Aldrich - S4139

Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine together with putrescine and spermine compose a family of biogenic polyamines (polycations) that are required for the survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycan, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols. Spermidine Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.

Sigma Aldrich - 85559

Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
Other Notes
Polyamines: Review1; Inhibitor of arginine decarboxylase2,3; and DNA polymerase4
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Sigma Aldrich - S3828

Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Sigma Aldrich - 85561

Caution
如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。
Other Notes
Polyamines: Review1
Biochem/physiol Actions
Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Toronto Research Chemicals - S680400

Spermidine is a biogenic polyamine formed from putrescine. Spermidine is a precursor of Spermine. Spermidine is essential for both normal and neoplastic tissue growth.

参考文献

• Abraham, A.K., et al.: Eur. J. Biochem., 106, 257 (1980)
• Mach, M., et al.: Biochem. J., 202, 153 (1980)
• Thyss, A., et al.: Eur. J. Cancer Clin. Oncol., 18, 611 (1980)